PMID- 15603871
OWN - NLM
STAT- MEDLINE
DCOM- 20050331
LR  - 20061115
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 65
IP  - 12
DP  - 2004 Dec
TI  - Different HLA-DR-DQ and MHC class I chain-related gene A (MICA) genotypes in 
      autoimmune and nonautoimmune gestational diabetes in a Swedish population.
PG  - 1443-50
AB  - The genetic susceptibility for gestational diabetes (GDM) was estimated by 
      comparisons of genotypes within human leukocyte antigen (HLA) and major 
      histocompatibility complex class I chain-related gene A (MICA) in 199 women with 
      GDM and 213 healthy women. At least one of ICA, glutamic acid decarboxylase 
      antibodies, or islet cell antigen-2 antibodies/tyrosine phosphatase antibodies 
      was found in 6.0% (12/199) of women with GDM and were considered as autoimmune 
      GDM, whereas the remaining 187 were considered as nonautoimmune GDM. HLA 
      genotyping was done with polymerase chain reaction and sequence-specific 
      oligonucleotides. MICA polymorphism was determined with polymerase chain reaction 
      and fragment size determination. HLA-DR3-DQ2/x or DR4-DQ8/x and MICA5.0/5.1 were 
      more frequent in autoimmune GDM compared with controls; 92% versus 46% and 42% 
      versus 13% and conferred increased risk (odds ratio [OR] = 13; 95% confidence 
      interval [CI] 1.7-104) and (OR = 4.7; 95%CI 1.4-16). Four other genotypes were 
      more frequent in nonautoimmune GDM compared with controls: HLA-DR7-DQ2/y, 24% 
      versus 14%; DR9-DQ9/y, 9.6% versus 1.9%; DR14-DQ5/y, 7.5% versus 0.94%; and 
      MICA5.0/z, 24% versus 13% and gave increased risk: OR = 2.0; 95%CI 1.2-3.4, OR = 
      5.6; 95%CI 1.8-17, OR = 8.5; 95%CI 1.9-38, and OR = 2.0; 95%CI 1.2-3.4, 
      respectively. We concluded that autoimmune diabetes with onset during pregnancy 
      is associated with the type 1 diabetes-associated genotypes and also with 
      MICA5.0/5.1, whereas DR7-DQ2/y, DR9-DQ9/y, DR14-DQ5/y, and MICA5.0/z are risk 
      factors for nonautoimmune GDM.
FAU - Torn, Carina
AU  - Torn C
AD  - Diabetes Laboratory, Institution of Medicine, Lund University, Lund University 
      Hospital, Lund, Sweden. Carina.Torn@med.lu.se
FAU - Gupta, Manu
AU  - Gupta M
FAU - Sanjeevi, Carani B
AU  - Sanjeevi CB
FAU - Aberg, Anders
AU  - Aberg A
FAU - Frid, Anders
AU  - Frid A
FAU - Landin-Olsson, Mona
AU  - Landin-Olsson M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (MHC class I-related chain A)
RN  - 0 (Proteins)
SB  - IM
MH  - Adult
MH  - Autoimmune Diseases/*genetics/*immunology
MH  - Case-Control Studies
MH  - Diabetes, Gestational/*genetics/*immunology
MH  - Female
MH  - Gene Frequency
MH  - Genes, MHC Class I
MH  - Genotype
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - Histocompatibility Antigens Class I
MH  - Humans
MH  - Middle Aged
MH  - Pregnancy
MH  - Proteins/*genetics
MH  - Risk Factors
MH  - Sweden
EDAT- 2004/12/18 09:00
MHDA- 2005/04/01 09:00
CRDT- 2004/12/18 09:00
PHST- 2004/07/15 00:00 [received]
PHST- 2004/08/27 00:00 [revised]
PHST- 2004/09/09 00:00 [accepted]
PHST- 2004/12/18 09:00 [pubmed]
PHST- 2005/04/01 09:00 [medline]
PHST- 2004/12/18 09:00 [entrez]
AID - S0198-8859(04)00622-6 [pii]
AID - 10.1016/j.humimm.2004.09.002 [doi]
PST - ppublish
SO  - Hum Immunol. 2004 Dec;65(12):1443-50. doi: 10.1016/j.humimm.2004.09.002.