PMID- 15603872
OWN - NLM
STAT- MEDLINE
DCOM- 20050331
LR  - 20211203
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 65
IP  - 12
DP  - 2004 Dec
TI  - HLA-B27 in the Greek Cypriot population: distribution of subtypes in patients 
      with ankylosing spondylitis and other HLA-B27-related diseases. The possible 
      protective role of B*2707.
PG  - 1451-4
AB  - The major purpose of the present study was to investigate the frequency of human 
      leukocyte antigen (HLA)-B27 alleles in healthy controls and in patients with 
      ankylosing spondylitis (AS) and other HLA-B27-related diseases in the Greek 
      Cypriot population. We selected 102 HLA-B27-positive individuals (60 controls and 
      42 patients). Typing of the HLA-B27 alleles was performed by polymerase chain 
      reaction amplification with sequence-specific primers. Only two alleles were 
      detected in the patient group: B*2702 (n = 31, 73.8%) and B*2705 (n = 11, 26.2%). 
      The HLA-B*2707 allele was detected (n = 10, 16.7%) only in the healthy controls 
      in addition to the B*2702 (n = 31, 51.7%) and B*2705 (n = 19, 31.7%) alleles. Our 
      results show a restricted number of HLA-B27 subtypes associated with AS and other 
      B27-related diseases and an elevated frequency of the B*2702 allele in the AS 
      patients. The allele B*2707 seems to have a protective role in the population 
      studied because it was found only in the healthy controls.
FAU - Varnavidou-Nicolaidou, Agathi
AU  - Varnavidou-Nicolaidou A
AD  - Histocompatibility and Immunogenetics Laboratory, Paraskevaidion Surgical and 
      Transplant Center, Nicosia, Cyprus. avarnavidou@transplant.com.cy
FAU - Karpasitou, Katerina
AU  - Karpasitou K
FAU - Georgiou, Dora
AU  - Georgiou D
FAU - Stylianou, Galatia
AU  - Stylianou G
FAU - Kokkofitou, Avgousta
AU  - Kokkofitou A
FAU - Michalis, Christodoulides
AU  - Michalis C
FAU - Constantina, Constantinou
AU  - Constantina C
FAU - Gregoriadou, Christiana
AU  - Gregoriadou C
FAU - Kyriakides, George
AU  - Kyriakides G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Alleles
MH  - Case-Control Studies
MH  - Ethnicity/genetics
MH  - Female
MH  - Gene Frequency
MH  - Greece
MH  - HLA-B27 Antigen/classification/*genetics
MH  - Humans
MH  - Male
MH  - Spondylarthropathies/genetics/immunology
MH  - Spondylitis, Ankylosing/*genetics/*immunology
EDAT- 2004/12/18 09:00
MHDA- 2005/04/01 09:00
CRDT- 2004/12/18 09:00
PHST- 2004/03/18 00:00 [received]
PHST- 2004/08/09 00:00 [revised]
PHST- 2004/08/11 00:00 [accepted]
PHST- 2004/12/18 09:00 [pubmed]
PHST- 2005/04/01 09:00 [medline]
PHST- 2004/12/18 09:00 [entrez]
AID - S0198-8859(04)00584-1 [pii]
AID - 10.1016/j.humimm.2004.08.177 [doi]
PST - ppublish
SO  - Hum Immunol. 2004 Dec;65(12):1451-4. doi: 10.1016/j.humimm.2004.08.177.