PMID- 15603875
OWN - NLM
STAT- MEDLINE
DCOM- 20050331
LR  - 20220316
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 65
IP  - 12
DP  - 2004 Dec
TI  - HLA class II haplotypes in Mexican systemic lupus erythematosus patients.
PG  - 1469-76
AB  - Systemic lupus erythematosus (SLE) is an autoimmune disease in which 
      polymorphisms within the human leukocyte antigen (HLA) region have been 
      associated to its etiology. For this study, HLA-DQB1, DQA1, and DRB1 genes were 
      typed by polymerase chain reaction-sequence-specific primer in 237 individuals, 
      taken from 74 families, who had a member with SLE, and who had their residence in 
      the western region of Mexico; as well as in 159 ethnically matched healthy 
      volunteers taken from 32 families. Genotype and allele frequency analysis was 
      performed in 74 SLE patients and 54 unrelated controls. Precise three-loci 
      identification of independent haplotypes was performed in 48 patients and 54 
      controls by familial segregation. Genotype distribution at each loci was 
      concordant with Hardy-Weinberg's equilibrium in the control group. In general, no 
      genotype effect was observed in SLE patients. Allele distribution comparison 
      showed in the SLE group a significant increase of HLA-DQA1*0102, DQB1*0402, and 
      DRB1*15; whereas alleles HLA-DQB1*0303 and *0501 were significantly decreased. 
      SLE patients showed haplotype DQB1*0602-DQA1-*0102-DRB1*15 increased. As 
      expected, patients with SLE have a reduced haplotype genetic diversity. The 
      associations found in this study are related to an ancestral haplotype that has 
      been observed in SLE populations of different origins.
FAU - Cortes, Lizette M
AU  - Cortes LM
AD  - Division of Immunology, HCMNO Instituto Mexicano del Seguro Social, Guadalajara, 
      Mexico. CortesL@nei.nih.gov
FAU - Baltazar, Luz M
AU  - Baltazar LM
FAU - Lopez-Cardona, Maria G
AU  - Lopez-Cardona MG
FAU - Olivares, Norma
AU  - Olivares N
FAU - Ramos, Cesar
AU  - Ramos C
FAU - Salazar, Mario
AU  - Salazar M
FAU - Sandoval, Lucila
AU  - Sandoval L
FAU - Lorenz, Matthias G O
AU  - Lorenz MG
FAU - Chakraborty, Ranajit
AU  - Chakraborty R
FAU - Paterson, Andrew D
AU  - Paterson AD
FAU - Rivas, Fernando
AU  - Rivas F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-D Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - *Genes, MHC Class II
MH  - Genotype
MH  - HLA-D Antigens/*genetics
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Humans
MH  - Lupus Erythematosus, Systemic/*genetics/*immunology
MH  - Male
MH  - Mexico
MH  - Middle Aged
EDAT- 2004/12/18 09:00
MHDA- 2005/04/01 09:00
CRDT- 2004/12/18 09:00
PHST- 2004/12/18 09:00 [pubmed]
PHST- 2005/04/01 09:00 [medline]
PHST- 2004/12/18 09:00 [entrez]
AID - S0198-8859(04)00634-2 [pii]
AID - 10.1016/j.humimm.2004.09.008 [doi]
PST - ppublish
SO  - Hum Immunol. 2004 Dec;65(12):1469-76. doi: 10.1016/j.humimm.2004.09.008.