PMID- 15603876
OWN - NLM
STAT- MEDLINE
DCOM- 20050331
LR  - 20211203
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 65
IP  - 12
DP  - 2004 Dec
TI  - HLA-DRB1 and -DQB1 alleles in mestizo patients with Vogt-Koyanagi-Harada's 
      disease in Southern California.
PG  - 1477-82
AB  - We evaluated human leukocyte antigen (HLA)-DRB1 and -DQB1 alleles as genetic 
      markers for Vogt-Koyanagi-Harada (VKH) disease in Mestizo patients in Southern 
      California. Mestizo individuals with VKH disease (n = 29) at two institutions 
      were evaluated. Typing of HLA-DRB1 and DQB1 genes was performed using DNA-based 
      techniques. Gene frequencies were compared to Mestizo individuals living in 
      Southern California. All patients had HLA-DRB1*01, DRB1*04, DQB1*03 or DQB1*05, 
      or a combination of these genes. The gene frequency of combined HLA-DR4 alleles 
      was increased when compared to controls. The frequencies of HLA-DRB1*0404 and 
      DRB1*0407 were increased compared to controls, but were not significant after 
      Bonferroni correction. Three patients had the HLA-DRB1*0410 allele; this allele 
      was not found in controls. All HLA-DRB1*01 positive patients had the DRB1*0102 
      subtype. No HLA-DQB1 allele was significantly increased compared to controls. 
      This study is the first to identify a possible association between HLA-DRB1*0404 
      and VKH disease, as well as to find DRB1*0102 and DRB1*0410 in Mestizo patients.
FAU - Levinson, Ralph D
AU  - Levinson RD
AD  - Ocular Inflammatory Disease Center, Jules Stein Eye Institute and Department of 
      Ophthalmology, Los Angeles, USA. levinson@jsei.ucla.edu
FAU - See, Robert F
AU  - See RF
FAU - Rajalingam, Raja
AU  - Rajalingam R
FAU - Reed, Elaine F
AU  - Reed EF
FAU - Park, Min S
AU  - Park MS
FAU - Rao, Narsing A
AU  - Rao NA
FAU - Holland, Gary N
AU  - Holland GN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - California
MH  - Case-Control Studies
MH  - Gene Frequency
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Hispanic or Latino/genetics
MH  - Humans
MH  - Uveomeningoencephalitic Syndrome/*genetics/*immunology
EDAT- 2004/12/18 09:00
MHDA- 2005/04/01 09:00
CRDT- 2004/12/18 09:00
PHST- 2004/04/01 00:00 [received]
PHST- 2004/07/08 00:00 [revised]
PHST- 2004/07/09 00:00 [accepted]
PHST- 2004/12/18 09:00 [pubmed]
PHST- 2005/04/01 09:00 [medline]
PHST- 2004/12/18 09:00 [entrez]
AID - S0198-8859(04)00395-7 [pii]
AID - 10.1016/j.humimm.2004.07.236 [doi]
PST - ppublish
SO  - Hum Immunol. 2004 Dec;65(12):1477-82. doi: 10.1016/j.humimm.2004.07.236.