PMID- 15603877
OWN - NLM
STAT- MEDLINE
DCOM- 20050331
LR  - 20111117
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 65
IP  - 12
DP  - 2004 Dec
TI  - HLA-DP polymorphism in Venezuelan Amerindians.
PG  - 1483-8
AB  - Three different Venezuelan Amerindian tribes were studied for human leukocyte 
      antigen (HLA)-DPA1 and DPB1 allelic variability using polymerase chain 
      reaction-sequence-specific oligonucleotide probes (PCR-SSOP) and sequence-based 
      typing in a selected group of samples. These tribes are geographically (two from 
      the Perija Mountain range and one from the Orinoco Delta) and linguistically 
      distinct: the Bari (from Campo Rosario and Saymaidoyi villages) and the Warao 
      have been classified within the Chibcha linguistic family, whereas the Yucpa 
      (from the Aroy, Marewa, and Peraya villages) are Carib speaking. Venezuelan 
      Indians, like other Native American tribes, show a markedly reduced number of 
      different HLA-DP alleles (range, 2-7) and haplotypes (range, 4-11) in comparison 
      with neighboring Venezuelan mestizo and other non-Indian populations. Some 
      HLA-DPB1 (*0402 and *1401) alleles characteristic for all Amerindian tribes are 
      present also in these populations. Despite general similarities, each tribe and, 
      in some cases, some subtribes show their own pattern of allele and haplotype 
      distribution apparently more as a result of linguistic than to geographic 
      variation.
FAU - Gendzekhadze, Ketevan
AU  - Gendzekhadze K
AD  - Laboratorio de Fisiopatologia, Instituto Venezolano de Investigaciones 
      Cientificas, Caracas, Venezuela.
FAU - Herrera, Fidias
AU  - Herrera F
FAU - Montagnani, Silvia
AU  - Montagnani S
FAU - Balbas, Omar
AU  - Balbas O
FAU - Witter, Klaus
AU  - Witter K
FAU - Albert, Ekkehard
AU  - Albert E
FAU - Layrisse, Zulay
AU  - Layrisse Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DP alpha-Chains)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPA1 antigen)
RN  - 0 (HLA-DPB1 antigen)
SB  - IM
MH  - Alleles
MH  - Gene Frequency
MH  - Genetic Variation
MH  - HLA-DP Antigens/*genetics
MH  - HLA-DP alpha-Chains
MH  - HLA-DP beta-Chains
MH  - Haplotypes
MH  - Humans
MH  - Indians, South American/classification/genetics
MH  - Linguistics
MH  - Phylogeny
MH  - Polymorphism, Genetic
MH  - Venezuela
EDAT- 2004/12/18 09:00
MHDA- 2005/04/01 09:00
CRDT- 2004/12/18 09:00
PHST- 2004/05/06 00:00 [received]
PHST- 2004/07/12 00:00 [revised]
PHST- 2004/07/14 00:00 [accepted]
PHST- 2004/12/18 09:00 [pubmed]
PHST- 2005/04/01 09:00 [medline]
PHST- 2004/12/18 09:00 [entrez]
AID - S0198-8859(04)00398-2 [pii]
AID - 10.1016/j.humimm.2004.07.238 [doi]
PST - ppublish
SO  - Hum Immunol. 2004 Dec;65(12):1483-8. doi: 10.1016/j.humimm.2004.07.238.