PMID- 15604121
OWN - NLM
STAT- MEDLINE
DCOM- 20050418
LR  - 20201226
IS  - 0741-5400 (Print)
IS  - 0741-5400 (Linking)
VI  - 77
IP  - 3
DP  - 2005 Mar
TI  - Dendritic cells and natural killer cells interact via multiple TNF family 
      molecules.
PG  - 408-13
AB  - Dendritic cells (DC) and natural killer (NK) cells are essential components of 
      the innate immune system, which rapidly sense and eliminate invading pathogens 
      and transformed cells, mediate inflammation, and initiate adaptive immune 
      responses. During the early immune events, DC and NK cells interact and regulate 
      each other. The cellular "cross talk" and its molecular mediators are believed to 
      be critical to the quality and magnitude of innate and adaptive immune responses. 
      The goal of the present manuscript is to identify and initially assess major 
      molecular mediators of DC-NK cell interaction. We have previously shown that DC 
      and NK cells constitutively express several tumor necrosis factor family ligands 
      (TNFfLs) and corresponding TNF family receptors (TNFfRs). Therefore, DC and NK 
      cells might be able to interact via cognate interplays of TNFfLs and TNFfRs. 
      Here, we provide initial experimental evidence supporting this possibility. We 
      found that combined but not individual ligation of several TNFfRs induced 
      substantial increases in secretion of interleukin-12 and interferon-gamma by DC 
      and NK cells, respectively. In contrast, specific, individual disruptions of the 
      engagements of the corresponding TNfL-TNFfR pairs greatly impaired DC and NK cell 
      abilities to reciprocally mediate the increases in cytokine secretion. These 
      findings indicate that multiple TNFfLs mediate DC-NK cell interaction.
FAU - Makarenkova, Valeria
AU  - Makarenkova V
AD  - Hillman Cancer Center, G.17d, 5117 Centre Avenue, Pittsburgh, PA 15213-1863, USA.
FAU - Chakrabarti, Ayan K
AU  - Chakrabarti AK
FAU - Liberatore, Jennifer A
AU  - Liberatore JA
FAU - Popovic, Petar
AU  - Popovic P
FAU - Lu, Ganwei
AU  - Lu G
FAU - Watkins, Simon
AU  - Watkins S
FAU - Vujanovic, Nikola L
AU  - Vujanovic NL
LA  - eng
GR  - 1P60 DE 13059/DE/NIDCR NIH HHS/United States
GR  - R01 DE 14775/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20041216
PL  - England
TA  - J Leukoc Biol
JT  - Journal of leukocyte biology
JID - 8405628
RN  - 0 (Ligands)
RN  - 0 (Receptors, Tumor Necrosis Factor)
SB  - IM
MH  - Animals
MH  - Cell Communication/immunology
MH  - Dendritic Cells/*immunology
MH  - Female
MH  - Killer Cells, Natural/*immunology
MH  - Ligands
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Models, Biological
MH  - Receptors, Tumor Necrosis Factor/*immunology
EDAT- 2004/12/18 09:00
MHDA- 2005/04/19 09:00
CRDT- 2004/12/18 09:00
PHST- 2004/12/18 09:00 [pubmed]
PHST- 2005/04/19 09:00 [medline]
PHST- 2004/12/18 09:00 [entrez]
AID - jlb.1104675 [pii]
AID - 10.1189/jlb.1104675 [doi]
PST - ppublish
SO  - J Leukoc Biol. 2005 Mar;77(3):408-13. doi: 10.1189/jlb.1104675. Epub 2004 Dec 16.