PMID- 15604330
OWN - NLM
STAT- MEDLINE
DCOM- 20050113
LR  - 20181113
IS  - 1468-201X (Electronic)
IS  - 1355-6037 (Print)
IS  - 1355-6037 (Linking)
VI  - 91
IP  - 1
DP  - 2005 Jan
TI  - Insulin resistance and inflammatory activation in older patients with systolic 
      and diastolic heart failure.
PG  - 32-7
AB  - OBJECTIVE: To evaluate insulin resistance and systemic inflammation in older 
      patients with systolic (SHF) or diastolic heart failure (DHF). PATIENTS: 52 
      non-diabetic patients (> 70 and < 90 years old) with chronic heart failure (CHF) 
      and hospitalised within the previous six months for heart failure were studied, 
      together with a control group of older healthy volunteers (n = 26). On the basis 
      of Doppler echocardiographic criteria patients were classed as having SHF (n = 
      27) or DHF (n = 25). MAIN OUTCOME MEASURES: Fasting glucose, insulin, C reactive 
      protein, interleukin 6, and tumour necrosis factor alpha soluble receptor II 
      (TNF-alphaSRII) concentrations were determined. Insulin resistance was estimated 
      by the homeostasis model assessment (HOMA). RESULTS: HOMA index (median, 
      interquartile range) was higher in patients with DHF (1.77, 1.06-2.26) than in 
      patients with SHF (0.97, 0.81-1.85) or healthy volunteers (1.04, 0.76-1.44; p = 
      0.01). After adjustment for body mass index, age, and use of angiotensin 
      converting enzyme inhibitors, both groups of patients with CHF were more insulin 
      resistant than were healthy volunteers (p = 0.02). C reactive protein, 
      interleukin 6, and TNF-alphaSRII were all significantly (p < 0.001) higher in 
      patients with DHF and SHF than in healthy volunteers. All markers of systemic 
      inflammation were independently associated with the presence of clinical CHF. 
      CONCLUSION: Insulin resistance and inflammatory activation are present in older 
      patients with SHF and DHF.
FAU - Wisniacki, N
AU  - Wisniacki N
AD  - Diabetes and Endocrinology Research Group, Department of Medicine, University of 
      Liverpool, Liverpool, UK. n.wisniacki@liv.ac.uk
FAU - Taylor, W
AU  - Taylor W
FAU - Lye, M
AU  - Lye M
FAU - Wilding, J P H
AU  - Wilding JP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Heart
JT  - Heart (British Cardiac Society)
JID - 9602087
RN  - 0 (Inflammation Mediators)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cross-Sectional Studies
MH  - Diastole
MH  - Echocardiography, Doppler
MH  - Female
MH  - Heart Failure/complications/diagnostic imaging/*physiopathology
MH  - Humans
MH  - Inflammation/*etiology
MH  - Inflammation Mediators/blood
MH  - *Insulin Resistance
MH  - Male
MH  - Norepinephrine/blood
MH  - Severity of Illness Index
MH  - Systole
PMC - PMC1768659
EDAT- 2004/12/18 09:00
MHDA- 2005/01/14 09:00
PMCR- 2008/01/01
CRDT- 2004/12/18 09:00
PHST- 2004/12/18 09:00 [pubmed]
PHST- 2005/01/14 09:00 [medline]
PHST- 2004/12/18 09:00 [entrez]
PHST- 2008/01/01 00:00 [pmc-release]
AID - 91/1/32 [pii]
AID - 0910032 [pii]
AID - 10.1136/hrt.2003.029652 [doi]
PST - ppublish
SO  - Heart. 2005 Jan;91(1):32-7. doi: 10.1136/hrt.2003.029652.