PMID- 15604430
OWN - NLM
STAT- MEDLINE
DCOM- 20050217
LR  - 20200306
IS  - 0022-1317 (Print)
IS  - 0022-1317 (Linking)
VI  - 86
IP  - Pt 1
DP  - 2005 Jan
TI  - A novel class of herpesvirus with bivalve hosts.
PG  - 41-53
LID - 10.1099/vir.0.80382-0 [doi]
AB  - Ostreid herpesvirus 1 (OsHV-1) is the only member of the Herpesviridae that has 
      an invertebrate host and is associated with sporadic mortality in the Pacific 
      oyster (Crassostrea gigas) and other bivalve species. Cryo-electron microscopy of 
      purified capsids revealed the distinctive T=16 icosahedral structure 
      characteristic of herpesviruses, although the preparations examined lacked 
      pentons. The gross genome organization of OsHV-1 was similar to that of certain 
      mammalian herpesviruses (including herpes simplex virus and human 
      cytomegalovirus), consisting of two invertible unique regions (U(L), 167.8 kbp; 
      U(S), 3.4 kbp) each flanked by inverted repeats (TR(L)/IR(L), 7.6 kbp; 
      TR(S)/IR(S), 9.8 kbp), with an additional unique sequence (X, 1.5 kbp) between 
      IR(L) and IR(S). Of the 124 unique genes predicted from the 207 439 bp genome 
      sequence, 38 were members of 12 families of related genes and encoded products 
      related to helicases, inhibitors of apoptosis, deoxyuridine triphosphatase and 
      RING-finger proteins, in addition to membrane-associated proteins. Eight genes in 
      three of the families appeared to be fragmented. Other genes that did not belong 
      to the families were predicted to encode DNA polymerase, the two subunits of 
      ribonucleotide reductase, a helicase, a primase, the ATPase subunit of terminase, 
      a RecB-like protein, additional RING-like proteins, an ion channel and several 
      other membrane-associated proteins. Sequence comparisons showed that OsHV-1 is at 
      best tenuously related to the two classes of vertebrate herpesviruses (those 
      associated with mammals, birds and reptiles, and those associated with bony fish 
      and amphibians). OsHV-1 thus represents a third major class of the herpesviruses.
FAU - Davison, Andrew J
AU  - Davison AJ
AD  - MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK.
FAU - Trus, Benes L
AU  - Trus BL
AD  - Laboratory of Structural Biology, National Institute of Arthritis, 
      Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 
      20892, USA.
AD  - Imaging Sciences Laboratory, Center for Information Technology, National 
      Institutes of Health, Bethesda, MD 20892, USA.
FAU - Cheng, Naiqian
AU  - Cheng N
AD  - Laboratory of Structural Biology, National Institute of Arthritis, 
      Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 
      20892, USA.
FAU - Steven, Alasdair C
AU  - Steven AC
AD  - Laboratory of Structural Biology, National Institute of Arthritis, 
      Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 
      20892, USA.
FAU - Watson, Moira S
AU  - Watson MS
AD  - MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK.
FAU - Cunningham, Charles
AU  - Cunningham C
AD  - MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK.
FAU - Deuff, Rose-Marie Le
AU  - Deuff RL
AD  - Laboratoire de Genetique et Pathologie, IFREMER, 17390 La Tremblade, France.
FAU - Renault, Tristan
AU  - Renault T
AD  - Laboratoire de Genetique et Pathologie, IFREMER, 17390 La Tremblade, France.
LA  - eng
SI  - GENBANK/AY509253
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Gen Virol
JT  - The Journal of general virology
JID - 0077340
RN  - 0 (Inhibitor of Apoptosis Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Proteins)
RN  - EC 3.6.1.- (Pyrophosphatases)
RN  - EC 3.6.1.23 (dUTP pyrophosphatase)
RN  - EC 3.6.4.- (DNA Helicases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Capsid/chemistry
MH  - DNA Helicases/genetics
MH  - *Genome, Viral
MH  - Herpesviridae/classification/*genetics/isolation & purification
MH  - Inhibitor of Apoptosis Proteins
MH  - Larva/virology
MH  - Membrane Proteins/genetics
MH  - Molecular Sequence Data
MH  - Ostreidae/*virology
MH  - Proteins/genetics
MH  - Pyrophosphatases/genetics
MH  - Sequence Alignment
EDAT- 2004/12/18 09:00
MHDA- 2005/02/18 09:00
CRDT- 2004/12/18 09:00
PHST- 2004/12/18 09:00 [pubmed]
PHST- 2005/02/18 09:00 [medline]
PHST- 2004/12/18 09:00 [entrez]
AID - 10.1099/vir.0.80382-0 [doi]
PST - ppublish
SO  - J Gen Virol. 2005 Jan;86(Pt 1):41-53. doi: 10.1099/vir.0.80382-0.