PMID- 15606375
OWN - NLM
STAT- MEDLINE
DCOM- 20050214
LR  - 20061115
IS  - 0954-6820 (Print)
IS  - 0954-6820 (Linking)
VI  - 257
IP  - 1
DP  - 2005 Jan
TI  - Surgery for gastroenteropancreatic tumours in multiple endocrine neoplasia type 
      1: review and personal experience.
PG  - 38-49
AB  - Multiple endocrine neoplasia type 1 (MEN1) gastro-entero-pancreatic (GEP) tumours 
      develop from the pancreatic islets and from the endocrine cells of the duodenal 
      and gastric mucosa. Even if GEP tumours have generally a benign course, a 
      subgroup of them shows an aggressive behaviour and is a major cause of death 
      amongst MEN1 patients. Diagnosis of insulinoma should lead promptly to pancreatic 
      surgery. MEN1 gastrinomas are multiple and almost exclusively localized in the 
      duodenum. Cure rate for Zollinger-Ellison syndrome in MEN1 is low when surgery is 
      limited to tumour enucleation or full thickness duodenal wall resection. 
      Conversely, pancreatoduodenectomy is followed by higher chance of cure. For 
      nonfunctioning tumours exceeding 1 cm diameter in size a prompt treatment is 
      recommended due to their high malignant potential. Gastroscopic surveillance is 
      indicated for the frequent occurrence of multiple, small, type 2 fundic 
      carcinoids. Endoscopic removal is possible for lesions growing in the 
      mucosa-submucosa, but partial or even total gastrectomy is recommended for the 
      small number of gastric carcinoids infiltrating the muscular layers.
FAU - Tonelli, F
AU  - Tonelli F
AD  - Department of Clinical Physiopathology, University of Florence, Florence, Italy. 
      f.tonelli@dfc.unifi.it
FAU - Fratini, G
AU  - Fratini G
FAU - Falchetti, A
AU  - Falchetti A
FAU - Nesi, G
AU  - Nesi G
FAU - Brandi, M L
AU  - Brandi ML
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - J Intern Med
JT  - Journal of internal medicine
JID - 8904841
SB  - IM
MH  - Gastrinoma/surgery
MH  - Gastrointestinal Neoplasms/*surgery
MH  - Humans
MH  - Insulinoma/surgery
MH  - Multiple Endocrine Neoplasia Type 1/*surgery
MH  - Neoplasm Metastasis/therapy
MH  - Pancreatic Neoplasms/surgery
MH  - Pancreaticoduodenectomy/methods
MH  - Prognosis
MH  - Stomach Neoplasms/surgery
MH  - Time Factors
RF  - 75
EDAT- 2004/12/21 09:00
MHDA- 2005/02/16 09:00
CRDT- 2004/12/21 09:00
PHST- 2004/12/21 09:00 [pubmed]
PHST- 2005/02/16 09:00 [medline]
PHST- 2004/12/21 09:00 [entrez]
AID - JIM1424 [pii]
AID - 10.1111/j.1365-2796.2004.01424.x [doi]
PST - ppublish
SO  - J Intern Med. 2005 Jan;257(1):38-49. doi: 10.1111/j.1365-2796.2004.01424.x.