PMID- 15607048
OWN - NLM
STAT- MEDLINE
DCOM- 20050715
LR  - 20131121
IS  - 0145-5680 (Print)
IS  - 0145-5680 (Linking)
VI  - 50 Online Pub
DP  - 2004
TI  - Improvement of the macrophage functions in prematurely ageing mice by a diet 
      supplemented with thiolic antioxidants.
PG  - OL677-81
AB  - In a model of prematurely ageing mice, based on the different behavioral response 
      in a simple T-maze test, we have studied in the present work the effect of a 
      short-term (five-weeks) ingestion of thioproline (TP) plus n-acetylcysteine (NAC) 
      (0.1% w/w of each antioxidant) on several functions of peritoneal macrophages 
      from female Swiss mice. The antioxidant treatment increased the chemotaxis, 
      phagocytosis and IL-1beta release and decreased the superoxide levels and 
      TNFalpha production. These effects were more striking in macrophages from 
      prematurely-ageing mice (PAM), than in those from the control group or 
      non-prematurely-ageing mice (NPAM), bringing the above functions of the PAM to 
      the NPAM levels. Diet supplementation with these thiolic compounds, namely TP and 
      NAC, seems an effective therapy for protection against early immune decline in 
      prematurely ageing mice.
FAU - Guayerbas, N
AU  - Guayerbas N
AD  - Department of Animal Physiology, Faculty of Biological Sciences, Complutense 
      University of Madrid, 28040 Madrid, Spain.
FAU - Puerto, M
AU  - Puerto M
FAU - Alvarez, P
AU  - Alvarez P
FAU - de la Fuente, M
AU  - de la Fuente M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Cell Mol Biol (Noisy-le-grand)
JT  - Cellular and molecular biology (Noisy-le-Grand, France)
JID - 9216789
RN  - 0 (Antioxidants)
RN  - 0 (Sulfhydryl Compounds)
RN  - 0 (Thiazoles)
RN  - 0 (Thiazolidines)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 11062-77-4 (Superoxides)
RN  - E5913T3IBL (thiazolidine-4-carboxylic acid)
RN  - WYQ7N0BPYC (Acetylcysteine)
SB  - IM
MH  - Acetylcysteine/administration & dosage/*therapeutic use
MH  - Aging, Premature/genetics/*prevention & control
MH  - Animals
MH  - Antioxidants/*therapeutic use
MH  - Chemotaxis/physiology
MH  - Diet
MH  - Female
MH  - Macrophages, Peritoneal/*drug effects/metabolism
MH  - Maze Learning/drug effects
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Phagocytosis/physiology
MH  - Sulfhydryl Compounds/therapeutic use
MH  - Superoxides/analysis/metabolism
MH  - Thiazoles/administration & dosage/*therapeutic use
MH  - Thiazolidines
MH  - Tumor Necrosis Factor-alpha/biosynthesis
EDAT- 2004/12/21 09:00
MHDA- 2005/07/16 09:00
CRDT- 2004/12/21 09:00
PHST- 2003/11/07 00:00 [received]
PHST- 2004/02/25 00:00 [accepted]
PHST- 2004/12/21 09:00 [pubmed]
PHST- 2005/07/16 09:00 [medline]
PHST- 2004/12/21 09:00 [entrez]
AID - OL677 [pii]
PST - ppublish
SO  - Cell Mol Biol (Noisy-le-grand). 2004;50 Online Pub:OL677-81.