PMID- 15608388
OWN - NLM
STAT- MEDLINE
DCOM- 20050421
LR  - 20211203
IS  - 1011-8934 (Print)
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Linking)
VI  - 19
IP  - 6
DP  - 2004 Dec
TI  - Production of chemokines in Kawasaki disease, Henoch-Schonlein purpura and acute 
      febrile illness.
PG  - 800-4
AB  - We compared the production of three chemokines; interferon-gamma-inducible 
      protein-10 (IP-10), monocyte chemoattractant protein-1 (MCP-1) and growth-related 
      onco-gene-alpha(Gro-alpha) that attracts monocytes or neutrophils, or both, in 
      peripheral blood at acute stage of Kawasaki disease (n=29), Henoch-Schonlein 
      purpura (n=15) and acute febrile illnesses (n=12). The production of the 
      chemokines was assayed by ELISA. The plasma levels of IP-10 were markedly 
      elevated in Kawasaki disease (538.6+/-336.4 pg/mL) and acute febrile illnesses 
      (417.1 +/-262.2 pg/mL) compared with in Henoch-Schonlein purpura (58.7 +/-95.7 
      pg/mL) (p<0.05). The MCP-1 levels were elevated in Kawasaki disease (443.0 
      +/-473.1 pg/mL) and acute febrile illnesses (328.6 +/-261.1 pg/mL) compared with 
      in Henoch-Schonlein purpura (82.9 +/-79.0 pg/mL) (p<0.05). The Gro-alpha levels 
      were elevated only in acute febrile illnesses (134.3 +/-153.6 pg/mL) compared 
      with in Kawasaki disease (31.8 +/-22.1 pg/mL) or Henoch-Schonlein purpura (29.4 
      +/-53.3 pg/mL) (p<0.05). According to these results, monocytes may play an 
      important role in Kawasaki disease. In acute febrile illnesses, both monocytes 
      and neutrophils may play an important role. By contrast, Henoch-Schonlein purpura 
      may not be associated with the role of monocytes and neutrophils. Further studies 
      using a larger number of cases are needed.
FAU - Chung, Hyo Seok
AU  - Chung HS
AD  - Department of Pediatrics, Yeungnam University, College of Medicine, Daegu, Korea.
FAU - Kim, Hyo Young
AU  - Kim HY
FAU - Kim, Hee Sun
AU  - Kim HS
FAU - Lee, Hee Jung
AU  - Lee HJ
FAU - Yuh, Ji Hyun
AU  - Yuh JH
FAU - Lee, Eun Sil
AU  - Lee ES
FAU - Choi, Kwang Hae
AU  - Choi KH
FAU - Lee, Young Hwan
AU  - Lee YH
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
RN  - 0 (Chemokines)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Chemokines/*blood
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Fever/*blood/*epidemiology
MH  - Humans
MH  - IgA Vasculitis/*blood/*epidemiology
MH  - Infant, Newborn
MH  - Korea/epidemiology
MH  - Male
MH  - Mucocutaneous Lymph Node Syndrome/*blood/*epidemiology
MH  - Risk Assessment/methods
MH  - Risk Factors
PMC - PMC2816295
EDAT- 2004/12/21 09:00
MHDA- 2005/04/22 09:00
PMCR- 2004/12/01
CRDT- 2004/12/21 09:00
PHST- 2004/12/21 09:00 [pubmed]
PHST- 2005/04/22 09:00 [medline]
PHST- 2004/12/21 09:00 [entrez]
PHST- 2004/12/01 00:00 [pmc-release]
AID - 200412800 [pii]
AID - 10.3346/jkms.2004.19.6.800 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2004 Dec;19(6):800-4. doi: 10.3346/jkms.2004.19.6.800.