PMID- 15610364
OWN - NLM
STAT- MEDLINE
DCOM- 20050526
LR  - 20080528
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 15
IP  - 6
DP  - 2004 Dec
TI  - Monocyte switch in neonates: high phagocytic capacity and low HLA-DR expression 
      in VLBWI are inverted during gestational aging.
PG  - 513-6
AB  - Pre-term neonates are at high risk to develop early-onset sepsis which possibly 
      is caused by an immature immune system. Monocytes play a pivotal role as 
      professional phagocytic and antigen-presenting cells in the innate immunity. In 
      the present study, we investigated in monocytes from cord blood the expression of 
      human leukocyte antigen (HLA)-DR as a marker for antigen-presenting capability, 
      the expression of the high-affinity receptor for IgG (FcgammaRI/CD64), and the 
      capacity to phagocytize non-opsonized Escherichia coli. We compared 70 infants in 
      three groups according to their gestational age (group I: 20 very low birth 
      weight infants (VLBWI), 24-31 weeks of gestation; group II: 25 pre-term infants, 
      32-36 weeks of gestation, and group III: 25 term neonates). The expression of 
      CD64 as well as the phagocytic capacity of monocytes from cord blood were highest 
      in VLBWI (p < 0.05 and p < 0.01, respectively). In contrast, HLA-DR expression 
      was significantly (p < 0.05) diminished in VLBWI, which possibly leads to a 
      reduced antigen-presenting capacity. We conclude that monocytes have different 
      functional properties during gestational aging, which perhaps participate in the 
      high incidence of infections in VLBWI.
FAU - Hallwirth, Ulrike
AU  - Hallwirth U
AD  - Department of Pediatric Surgery, University of Graz, Graz, Austria.
FAU - Pomberger, Gerhard
AU  - Pomberger G
FAU - Pollak, Arnold
AU  - Pollak A
FAU - Roth, Erich
AU  - Roth E
FAU - Spittler, Andreas
AU  - Spittler A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Age Factors
MH  - Analysis of Variance
MH  - Escherichia coli/immunology
MH  - Fetal Blood/immunology
MH  - Flow Cytometry/methods
MH  - *Gestational Age
MH  - HLA-DR Antigens/*biosynthesis/*blood
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Very Low Birth Weight/*immunology
MH  - Monocytes/*immunology
MH  - Phagocytosis/immunology/*physiology
EDAT- 2004/12/22 09:00
MHDA- 2005/05/27 09:00
CRDT- 2004/12/22 09:00
PHST- 2004/12/22 09:00 [pubmed]
PHST- 2005/05/27 09:00 [medline]
PHST- 2004/12/22 09:00 [entrez]
AID - PAI168 [pii]
AID - 10.1111/j.1399-3038.2004.00168.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2004 Dec;15(6):513-6. doi: 
      10.1111/j.1399-3038.2004.00168.x.