PMID- 15610365
OWN - NLM
STAT- MEDLINE
DCOM- 20050526
LR  - 20080528
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 15
IP  - 6
DP  - 2004 Dec
TI  - Effect of omega-3 fatty acid concentrations in plasma on symptoms of asthma at 18 
      months of age.
PG  - 517-22
AB  - The objective of this study was to assess the relation between observed levels of 
      omega-3 fatty acids in plasma and symptoms of asthma and atopy in children at 18 
      months of age. A total of 616 women at risk of having a child who would develop 
      asthma because of a family history were recruited from the antenatal clinics of 
      six hospitals in Sydney, Australia. Families were randomized to either active 
      omega-3 supplemented or control group. The active group received a daily tuna 
      fish oil supplement and omega-3-rich margarines and cooking oils and the control 
      group received a placebo supplement with polyunsaturated margarines and cooking 
      oils. When the children were 18 months of age an assessment of symptoms was 
      carried out by a research nurse blinded to treatment group allocation. Atopy was 
      measured by skin prick tests, blood was collected to determine serum 
      immunoglobulin E (IgE), and plasma fatty acid concentrations. A total of 376 
      children (61.0% of total recruited) completed an assessment at 18 months and had 
      blood taken to determine plasma fatty acid concentrations. Omega-3 fatty acid 
      levels were expressed in quintiles of exposure 'as treated' without reference to 
      treatment group allocation. Wheeze ever, doctor visits for wheeze, bronchodilator 
      use and nocturnal coughing were significantly reduced in children in the higher 
      exposure quintiles. Serum IgE was reduced in the highest quintile but not 
      significantly so. There was no difference in diagnosed asthma or atopy between 
      the exposure quintiles. Although wheeze at this age may not be a good indicator 
      of asthma in later childhood, it is encouraging that some symptoms have been 
      reduced in children with high omega-3 fatty acid concentrations in plasma.
FAU - Mihrshahi, Seema
AU  - Mihrshahi S
AD  - Clinical Epidemiology Unit, The Children's Hospital at Westmead, NSW, Australia. 
      seemam@chw.edu.au
FAU - Peat, Jennifer K
AU  - Peat JK
FAU - Webb, Karen
AU  - Webb K
FAU - Oddy, Wendy
AU  - Oddy W
FAU - Marks, Guy B
AU  - Marks GB
FAU - Mellis, Craig M
AU  - Mellis CM
CN  - CAPS Team
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Tobacco Smoke Pollution)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Asthma/*blood/complications/*prevention & control
MH  - Australia
MH  - Breast Feeding
MH  - Chi-Square Distribution
MH  - Dietary Supplements
MH  - Dose-Response Relationship, Drug
MH  - Fatty Acids, Omega-3/administration & dosage/*blood
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Male
MH  - Respiratory Sounds/etiology
MH  - Sex Factors
MH  - Skin Tests/methods
MH  - Tobacco Smoke Pollution/adverse effects
MH  - Treatment Outcome
EDAT- 2004/12/22 09:00
MHDA- 2005/05/27 09:00
CRDT- 2004/12/22 09:00
PHST- 2004/12/22 09:00 [pubmed]
PHST- 2005/05/27 09:00 [medline]
PHST- 2004/12/22 09:00 [entrez]
AID - PAI187 [pii]
AID - 10.1111/j.1399-3038.2004.00187.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2004 Dec;15(6):517-22. doi: 
      10.1111/j.1399-3038.2004.00187.x.