PMID- 15610371
OWN - NLM
STAT- MEDLINE
DCOM- 20050526
LR  - 20080528
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 15
IP  - 6
DP  - 2004 Dec
TI  - A randomized, single-blind and crossover study of an amino acid-based milk 
      formula in treating young children with atopic dermatitis.
PG  - 558-61
AB  - Cow's milk and soy protein allergies are commonly associated with atopic 
      dermatitis (AD) in young children. Amino acid (AA)-based elemental milk formula 
      may improve AD control in these patients. This study investigates the efficacy of 
      AA-based formula in treating young AD patients irrespective of their food allergy 
      status. AD patients younger than 3 yr old were eligible. Sensitization to food 
      allergens was ascertained by skin prick tests and allergen-specific 
      immunoglobulin E (IgE) assay. Patients were then randomly allocated to take 
      either active treatment or pre-existing formulae (placebo) for 6 wk. They were 
      allowed a 6-wk washout period before crossed over to the other intervention for 
      another 6 wk. Fifteen AD patients, with median (interquartile range, IQR) age of 
      1.4 (0.6-2.6) yr, were recruited. Their median (IQR) SCORAD score was 23.9 
      (10.5-29.7). Seven of them were sensitized to cow's milk or soybean. Among 11 
      patients who completed the study, the median changes for all scores and urinary 
      eosinophil protein X (EPX) concentration were not statistically significant. 
      There was also no evidence of carry-over effects for SCORAD and its various 
      components and global health score, except for urinary EPX concentration (p = 
      0.05). Our results do not support the use of AA-based elemental milk formula in 
      treating young children with AD irrespective of their food allergy status.
FAU - Leung, Ting Fan
AU  - Leung TF
AD  - Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong. 
      leung2142@cuhk.edu.hk
FAU - Ma, Kwok Chiu
AU  - Ma KC
FAU - Cheung, Lorena T F
AU  - Cheung LT
FAU - Lam, Christopher W K
AU  - Lam CW
FAU - Wong, Eric
AU  - Wong E
FAU - Wan, Helene
AU  - Wan H
FAU - Hon, Ellis K L
AU  - Hon EK
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Amino Acids)
SB  - IM
MH  - Amino Acids/*administration & dosage
MH  - Child, Preschool
MH  - Cross-Over Studies
MH  - Dermatitis, Atopic/*diet therapy
MH  - Dietary Supplements
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant Formula/*administration & dosage
MH  - Male
MH  - Severity of Illness Index
MH  - Single-Blind Method
MH  - Skin Tests/methods
MH  - Statistics, Nonparametric
MH  - Treatment Outcome
EDAT- 2004/12/22 09:00
MHDA- 2005/05/27 09:00
CRDT- 2004/12/22 09:00
PHST- 2004/12/22 09:00 [pubmed]
PHST- 2005/05/27 09:00 [medline]
PHST- 2004/12/22 09:00 [entrez]
AID - PAI197 [pii]
AID - 10.1111/j.1399-3038.2004.00197.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2004 Dec;15(6):558-61. doi: 
      10.1111/j.1399-3038.2004.00197.x.