PMID- 15610934
OWN - NLM
STAT- MEDLINE
DCOM- 20050204
LR  - 20151119
IS  - 0278-5846 (Print)
IS  - 0278-5846 (Linking)
VI  - 28
IP  - 7
DP  - 2004 Nov
TI  - Nicotine treatment of obsessive-compulsive disorder.
PG  - 1195-9
AB  - Following initial observations of marked effects of nicotine self-medication in a 
      patient with obsessive-compulsive disorder (OCD), another four OCD patients were 
      treated with nicotine for eight weeks in an open label fashion. Patients 
      fulfilling DSM-IV criteria for OCD and with initial Yale-Brown 
      Obsessive-Compulsive Scale (YBOCS) score>15 were included in the study. The 
      patients were scored with YBOCS, Beck Depression Inventory (BDI), Beck Anxiety 
      Inventory (BAI), NIMH Global Obsessive-Compulsive Scale (NIMH) and Global 
      Assessment of Functioning (GAF). Four of five patients receiving nicotine 
      treatment displayed a favourable response with reductions in YBOCS scores. For 
      these four patients, the nicotine chewing gum enabled a more adequate behaviour 
      in stressful, OCD-eliciting, situations. We feel that these results are 
      encouraging enough to warrant a larger, controlled study on nicotine treatment of 
      OCD.
FAU - Lundberg, Stefan
AU  - Lundberg S
AD  - Psychiatric Clinic, Kungalvs Sjukhus, Kungalv, Sweden.
FAU - Carlsson, Arvid
AU  - Carlsson A
FAU - Norfeldt, Per
AU  - Norfeldt P
FAU - Carlsson, Maria L
AU  - Carlsson ML
LA  - eng
PT  - Case Reports
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Nicotinic Agonists)
RN  - 6M3C89ZY6R (Nicotine)
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - Nicotine/*therapeutic use
MH  - Nicotinic Agonists/*therapeutic use
MH  - Obsessive-Compulsive Disorder/*drug therapy/psychology
MH  - Psychiatric Status Rating Scales
MH  - Stress, Psychological/psychology
EDAT- 2004/12/22 09:00
MHDA- 2005/02/05 09:00
CRDT- 2004/12/22 09:00
PHST- 2004/06/29 00:00 [accepted]
PHST- 2004/12/22 09:00 [pubmed]
PHST- 2005/02/05 09:00 [medline]
PHST- 2004/12/22 09:00 [entrez]
AID - S0278-5846(04)00140-X [pii]
AID - 10.1016/j.pnpbp.2004.06.014 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2004 Nov;28(7):1195-9. doi: 
      10.1016/j.pnpbp.2004.06.014.