PMID- 15611878
OWN - NLM
STAT- MEDLINE
DCOM- 20050705
LR  - 20221207
IS  - 0340-3696 (Print)
IS  - 0340-3696 (Linking)
VI  - 296
IP  - 8
DP  - 2005 Feb
TI  - The correlation between monocyte chemoattractant protein-1 and the arthritis of 
      systemic lupus erythematosus among Chinese.
PG  - 366-71
AB  - Monocyte chemoattractant protein-1 (MCP1) polymorphism has been reported to be 
      associated with systemic lupus erythematosus (SLE). However, the correlation 
      between the polymorphism and SLE is poorly understood. In this study we 
      investigated the role of this polymorphism together with that of chemokine 
      SDF1-3'A and chemokine receptor CCR2-V64I. The association between gene 
      polymorphism and SLE was explored by way of a case-control study. In 143 patients 
      with SLE and 157 healthy controls, the polymorphisms of SDF1-3'A, -2518MCP-1 and 
      CCR2-V64I were determined using PCR-RFLP and an amplification-refractory mutation 
      system, respectively. No significant difference was found in allelic and genotype 
      frequency of SDF1-3'A, CCR2-V64I and -2518MCP-1 between SLE patients and 
      controls. However, a significant increase in the frequency of the AG genotype of 
      MCP-1 was found among patients with arthritis (P(c)=0.003, OR 3.08, 95%CI 
      1.27-7.57). The frequency of individuals having G at position -2518 of the MCP-1 
      gene was also increased among patients with arthritis (P(c)=0.028, OR 2.99, 95%CI 
      1.13-8.08). It is noteworthy that the frequency of -2518MCP-1G in the Chinese Han 
      population was 64%. The results indicate an association between the presence of G 
      at position -2518 in the MCP-1 promoter region and the presence of arthritis in 
      patients with SLE.
FAU - Ye, Dong Qing
AU  - Ye DQ
AD  - Department of Epidemiology and Biostatistics, Anhui Medical University, 69 
      Meishan Road, Hefei, 230032, Anhui, People's Republic of China. 
      cjdcp@mail.hf.ah.cn
FAU - Hu, Yi Song
AU  - Hu YS
FAU - Li, Xiang Pei
AU  - Li XP
FAU - Yang, Shi Gui
AU  - Yang SG
FAU - Hao, Jia Hu
AU  - Hao JH
FAU - Huang, Fen
AU  - Huang F
FAU - Zhang, Xue Jun
AU  - Zhang XJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20041221
PL  - Germany
TA  - Arch Dermatol Res
JT  - Archives of dermatological research
JID - 8000462
RN  - 0 (CCR2 protein, human)
RN  - 0 (CXCL12 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CXCL12)
RN  - 0 (Chemokines)
RN  - 0 (Chemokines, CXC)
RN  - 0 (Receptors, CCR2)
RN  - 0 (Receptors, Chemokine)
RN  - 04Y7590D77 (Isoleucine)
RN  - 5Z93L87A1R (Guanine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Arthritis/*etiology/*genetics
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - Chemokine CCL2/*genetics
MH  - Chemokine CXCL12
MH  - Chemokines/genetics
MH  - Chemokines, CXC/genetics
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Guanine
MH  - Humans
MH  - Isoleucine
MH  - Lupus Erythematosus, Systemic/complications/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Promoter Regions, Genetic/genetics
MH  - Receptors, CCR2
MH  - Receptors, Chemokine/genetics
MH  - Valine
EDAT- 2004/12/22 09:00
MHDA- 2005/07/06 09:00
CRDT- 2004/12/22 09:00
PHST- 2004/07/18 00:00 [received]
PHST- 2004/11/11 00:00 [accepted]
PHST- 2004/11/02 00:00 [revised]
PHST- 2004/12/22 09:00 [pubmed]
PHST- 2005/07/06 09:00 [medline]
PHST- 2004/12/22 09:00 [entrez]
AID - 10.1007/s00403-004-0531-y [doi]
PST - ppublish
SO  - Arch Dermatol Res. 2005 Feb;296(8):366-71. doi: 10.1007/s00403-004-0531-y. Epub 
      2004 Dec 21.