PMID- 15611976
OWN - NLM
STAT- MEDLINE
DCOM- 20050222
LR  - 20050201
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 103
IP  - 3
DP  - 2005 Feb 1
TI  - Bronchopulmonary carcinoid in multiple endocrine neoplasia type 1.
PG  - 509-15
AB  - BACKGROUND: Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal-dominant 
      syndrome associated with neoplasia of pituitary, pancreas, parathyroid, and 
      foregut lineage neuroendocrine tissue. Although enteropancreatic carcinoid has 
      been well described in patients with MEN 1, it was believed that bronchopulmonary 
      carcinoid was relatively uncommon, occurring in approximately 5% of patients. It 
      is unclear whether the increased screening of asymptomatic patients with MEN 1 
      will facilitate early diagnosis of this tumor and improve patient prognosis. 
      METHODS: The authors reviewed the patient records and, when available, thoracic 
      computed tomographic (CT) images of 129 MEN 1-affected adult members of a single 
      family to determine the prevalence and prognosis of bronchopulmonary nodules and 
      carcinoid. RESULTS: Among 129 patients, a diagnosis of bronchopulmonary carcinoid 
      was noted in the records for 6 individuals (1 male and 5 females; 5%). Thoracic 
      CT scans also were available for review from 32 of those patients. Twelve 
      patients (38%) had pulmonary nodules evident on CT scans. Only hypergastrinemia 
      was significantly more common in patients with pulmonary nodules; otherwise, the 
      spectrum of neoplasia was similar between individuals with and without pulmonary 
      lesions. Histologic diagnoses were available in four patients (three female) with 
      abnormal CT images, and carcinoid was confirmed in each patient. No deaths or 
      distant metastases occurred among the patients despite long-term follow-up (mean, 
      127 months). CONCLUSIONS: The findings suggested that bronchopulmonary carcinoid 
      is more prevalent in patients with MEN 1 than was recognized previously. 
      Furthermore, the diagnosis did not appear to portend a poor prognosis in the 
      majority of affected patients.
CI  - (c) 2004 American Cancer Society
FAU - Sachithanandan, Nirupa
AU  - Sachithanandan N
AD  - Department of Diabetes and Endocrinology, Royal Hobart Hospital, Hobart, 
      Tasmania, Australia.
FAU - Harle, Robin A
AU  - Harle RA
FAU - Burgess, John R
AU  - Burgess JR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
SB  - IM
MH  - Adult
MH  - Bronchial Neoplasms/*complications
MH  - Carcinoid Tumor/*complications
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/*complications
MH  - Male
MH  - Medical Records
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*complications
MH  - Retrospective Studies
MH  - Tomography, X-Ray Computed
EDAT- 2004/12/22 09:00
MHDA- 2005/02/23 09:00
CRDT- 2004/12/22 09:00
PHST- 2004/12/22 09:00 [pubmed]
PHST- 2005/02/23 09:00 [medline]
PHST- 2004/12/22 09:00 [entrez]
AID - 10.1002/cncr.20825 [doi]
PST - ppublish
SO  - Cancer. 2005 Feb 1;103(3):509-15. doi: 10.1002/cncr.20825.