PMID- 15612689
OWN - NLM
STAT- MEDLINE
DCOM- 20050228
LR  - 20131121
IS  - 0002-7863 (Print)
IS  - 0002-7863 (Linking)
VI  - 126
IP  - 51
DP  - 2004 Dec 29
TI  - c-di-GMP displays a monovalent metal ion-dependent polymorphism.
PG  - 16700-1
AB  - Cyclic diguanosine monophosphate (c-di-GMP) is known to be an important signaling 
      molecule that regulates the formation of bacterial biofilms. We demonstrate here 
      by UV, CD, and NMR that it displays a surprising polymorphism that varies with 
      the monovalent counterion and is consistent with the formation of a G-quartet 
      structure in K+ and a stacked structure in Li+ or Na+. The ability of this rigid 
      molecule to adopt different alignments may be important to its biological role.
FAU - Zhang, Zhaoying
AU  - Zhang Z
AD  - Department of Chemistry and Chemical Biology, 610 Taylor Road, Rutgers, The State 
      University of New Jersey, Piscataway, NJ 08854, USA.
FAU - Gaffney, Barbara L
AU  - Gaffney BL
FAU - Jones, Roger A
AU  - Jones RA
LA  - eng
GR  - EB 002809/EB/NIBIB NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Am Chem Soc
JT  - Journal of the American Chemical Society
JID - 7503056
RN  - 0 (Cations, Monovalent)
RN  - 0 (Metals, Alkali)
RN  - 61093-23-0 (bis(3',5')-cyclic diguanylic acid)
RN  - H2D2X058MU (Cyclic GMP)
SB  - IM
MH  - Cations, Monovalent
MH  - Circular Dichroism
MH  - Cyclic GMP/*analogs & derivatives/*chemistry
MH  - Metals, Alkali/*chemistry
MH  - Nuclear Magnetic Resonance, Biomolecular
MH  - Spectrophotometry, Ultraviolet
EDAT- 2004/12/23 09:00
MHDA- 2005/03/01 09:00
CRDT- 2004/12/23 09:00
PHST- 2004/12/23 09:00 [pubmed]
PHST- 2005/03/01 09:00 [medline]
PHST- 2004/12/23 09:00 [entrez]
AID - 10.1021/ja0449832 [doi]
PST - ppublish
SO  - J Am Chem Soc. 2004 Dec 29;126(51):16700-1. doi: 10.1021/ja0449832.