PMID- 15613143
OWN - NLM
STAT- MEDLINE
DCOM- 20050310
LR  - 20151113
IS  - 1351-5101 (Print)
IS  - 1351-5101 (Linking)
VI  - 12
IP  - 1
DP  - 2005 Jan
TI  - Optic neuritis, multiple sclerosis and human leukocyte antigen: results of a 
      4-year follow-up study.
PG  - 25-30
AB  - In the present study the relation between human leukocyte antigen (HLA), optic 
      neuritis (ON) and multiple sclerosis (MS) has been investigated in 56 Iranian 
      patients (46 females and 10 males). HLA-A and -B typing by 
      microlymphocytotoxicity method and HLA-DRB, DQA and DQB by polymerase chain 
      reaction based on sequence specific primers method was performed for the selected 
      patients with ON. The diagnosis of clinically defined MS (CDMS) was confirmed in 
      15 of them (26.7%) during their follow-up. HLA-A24 was significantly higher in ON 
      patients, whilst A23, A26, and A30 showed a significant decrease in these 
      patients. HLA-A10 and A26 were absent in CDMS patients and A2 and A11 were 
      significantly decreased in ON and CDMS patients. HLA-B5, B51, B38, B27, and B35 
      were significantly increased in ON patients compared with control subjects. 
      HLA-B44, B16 and B38 alleles were not present in CDMS patients. Regarding DR 
      locus, the frequency of HLA-DRB1*15 and DRB1*04 has been increased in CDMS 
      patients, whilst the frequency of HLA-DRB1*07 and *11 was much higher in ON 
      patients. In DQA region, the most frequent allele in the MS patients was 
      DQA1*0102, which was significantly higher than ON patients, and control group. 
      The frequency of DQA1*0103 was significantly increased in both patients group. In 
      DQB1, the frequency of DQB1*0602 increased significantly in the MS patients. In 
      conclusion existence of common genetic basis for early manifestations of MS could 
      be suggested.
FAU - Amirzargar, A A
AU  - Amirzargar AA
AD  - Immunogenetic Laboratory, Department of Immunology, Tehran University of Medical 
      Sciences, Tehran, Iran. amirzargar_ali@yahoo.com
FAU - Tabasi, A
AU  - Tabasi A
FAU - Khosravi, F
AU  - Khosravi F
FAU - Kheradvar, A
AU  - Kheradvar A
FAU - Rezaei, N
AU  - Rezaei N
FAU - Naroueynejad, M
AU  - Naroueynejad M
FAU - Ansaripour, B
AU  - Ansaripour B
FAU - Moradi, B
AU  - Moradi B
FAU - Nikbin, B
AU  - Nikbin B
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Eur J Neurol
JT  - European journal of neurology
JID - 9506311
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Child
MH  - Confidence Intervals
MH  - Female
MH  - Follow-Up Studies
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - *Histocompatibility Testing/methods
MH  - Humans
MH  - Male
MH  - Multiple Sclerosis/genetics/*immunology
MH  - Odds Ratio
MH  - Optic Neuritis/genetics/*immunology
EDAT- 2004/12/23 09:00
MHDA- 2005/03/11 09:00
CRDT- 2004/12/23 09:00
PHST- 2004/12/23 09:00 [pubmed]
PHST- 2005/03/11 09:00 [medline]
PHST- 2004/12/23 09:00 [entrez]
AID - ENE901 [pii]
AID - 10.1111/j.1468-1331.2004.00901.x [doi]
PST - ppublish
SO  - Eur J Neurol. 2005 Jan;12(1):25-30. doi: 10.1111/j.1468-1331.2004.00901.x.