PMID- 15613857
OWN - NLM
STAT- MEDLINE
DCOM- 20050208
LR  - 20190823
IS  - 0147-5185 (Print)
IS  - 0147-5185 (Linking)
VI  - 29
IP  - 1
DP  - 2005 Jan
TI  - Clinicopathologic, immunophenotypic, and molecular cytogenetic fluorescence in 
      situ hybridization analysis of primary and secondary cutaneous follicular 
      lymphomas.
PG  - 69-82
AB  - Although primary cutaneous follicular lymphoma (FL) is considered a distinct 
      variant of FL in the World Health Organization classification ("cutaneous 
      follicle center lymphoma"), its biologic relationship to nodal FL remains 
      controversial. The clinical, morphologic, immunophenotypic, and molecular 
      cytogenetic features of 17 patients with primary cutaneous FL were studied and 
      compared with 16 patients with secondary cutaneous FL. The head and neck region 
      was the most frequent site at initial skin presentation in both the primary and 
      secondary cases. Among the primary cases, 29% of the 31 biopsies were grade 1, 
      48% grade 2, 13% grade 3, and 10% grade 3 with diffuse large B-cell (DLBCL) 
      areas. Among the secondary cases, 38% of the 29 skin biopsies were grade 1, 45% 
      grade 2, 3% grade 3, and 7% grade 3 with DLBCL areas with two not evaluable. A 
      floral-like pattern was observed in 32% of primary FL but only 5% of secondary 
      cases. Histologic progression was found in 21% of patients. CD10 expression was 
      demonstrated in 90% (27 of 30) of primary cases and 96% (22 of 23) of secondary 
      cases. Bcl-6 was expressed in all cases tested. Bcl-2 expression was detected in 
      57% (17 of 30) of the primary cases (100% of grade 1, 43% of grade 2, 40% of 
      grade 3), whereas all secondary cases were bcl-2 positive (P=0.0002). The 
      t(14;18) translocation was identified by interphase fluorescence in situ 
      hybridization (FISH) in biopsies from 31% (4 of 13) of the patients with primary 
      FL compared with 77% (10 of 13) of those with secondary lymphoma (P <0.05). Seven 
      of the 17 (41%) patients with primary disease had cutaneous relapse, including 1 
      who also developed nodal disease. Bcl-2 positivity was seen in 4 of these 7 
      patients. Eight of the 16 (50%) patients with secondary FL had cutaneous relapse. 
      Primary and secondary cutaneous FL share many clinical and phenotypic features, 
      but primary cases may have some distinctive morphologic features, more frequently 
      lack bcl-2 protein, and often lack the t(14;18) translocation. These findings 
      suggest that primary cutaneous FL are distinctive and often but not always have a 
      pathogenesis different from most of nodal and secondary cutaneous FL.
FAU - Kim, Bong K
AU  - Kim BK
AD  - Department of Pathology, Division of Hematopathology, University of Pittsburgh 
      Medical Center, Pittsburgh, PA 15213, USA.
FAU - Surti, Urvashi
AU  - Surti U
FAU - Pandya, Amit
AU  - Pandya A
FAU - Cohen, Jack
AU  - Cohen J
FAU - Rabkin, Michael S
AU  - Rabkin MS
FAU - Swerdlow, Steven H
AU  - Swerdlow SH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Surg Pathol
JT  - The American journal of surgical pathology
JID - 7707904
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (DNA, Neoplasm)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Proto-Oncogene Proteins c-bcl-6)
RN  - 0 (Transcription Factors)
RN  - EC 3.4.24.11 (Neprilysin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/metabolism
MH  - Chromosomes, Human, Pair 14
MH  - Chromosomes, Human, Pair 18
MH  - DNA, Neoplasm/analysis
MH  - DNA-Binding Proteins/metabolism
MH  - Female
MH  - Head and Neck Neoplasms/metabolism/*pathology
MH  - Humans
MH  - Immunophenotyping
MH  - *In Situ Hybridization, Fluorescence
MH  - Lymphoma, Follicular/genetics/metabolism/*pathology
MH  - Male
MH  - Middle Aged
MH  - Neprilysin/metabolism
MH  - Proto-Oncogene Proteins/metabolism
MH  - Proto-Oncogene Proteins c-bcl-6
MH  - Skin Neoplasms/genetics/metabolism/*pathology
MH  - Transcription Factors/metabolism
MH  - Translocation, Genetic
EDAT- 2004/12/23 09:00
MHDA- 2005/02/09 09:00
CRDT- 2004/12/23 09:00
PHST- 2004/12/23 09:00 [pubmed]
PHST- 2005/02/09 09:00 [medline]
PHST- 2004/12/23 09:00 [entrez]
AID - 00000478-200501000-00007 [pii]
AID - 10.1097/01.pas.0000146015.22624.c7 [doi]
PST - ppublish
SO  - Am J Surg Pathol. 2005 Jan;29(1):69-82. doi: 10.1097/01.pas.0000146015.22624.c7.