PMID- 15614146
OWN - NLM
STAT- MEDLINE
DCOM- 20050131
LR  - 20190713
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 78
IP  - 12
DP  - 2004 Dec 27
TI  - Reduced-intensity allogeneic hematopoietic stem-cell transplantation as an 
      immunotherapy for metastatic colorectal cancer.
PG  - 1740-6
AB  - BACKGROUND: Allogeneic stem-cell transplantation (allo-SCT) can induce curative 
      graft-versus-leukemia reactions for hematologic malignancies through allogeneic 
      immunity. Because the gastrointestinal tract is a target of graft-versus-host 
      disease (GvHD), colorectal cancer might be a candidate for allo-SCT. METHODS: 
      Four patients with metastatic colorectal cancer underwent reduced-intensity 
      stem-cell transplantation (RIST) in the National Cancer Center Hospital between 
      July 2002 and February 2003. Three patients received transplants from an human 
      leukocyte antigen (HLA)-identical related donor, and the remaining patient 
      received selected CD34-positive cells from a two-loci HLA-mismatched donor. The 
      basis of preparative regimen was busulfan 4 mg/kg for 2 days and fludarabine 25 
      mg/kg for 6 days. RESULTS: All the patients tolerated the preparative regimen and 
      achieved engraftment without significant toxicities. All developed acute or 
      chronic GvHD. Although serum levels of CA19-9 and carcinoembryonic antigen were 
      transiently elevated after RIST in all the patients, the levels subsequently 
      decreased below the levels from before RIST in all but one patient. Three had 
      measurable lesions before RIST, one achieved partial response, and the others 
      stable disease, which was durable for 120 and 60 days. Three patients died; the 
      causes of death were progressive disease, GvHD, and accident. Postmortem 
      examination was obtained for two patients; in one patient, the peritoneal 
      metastatic lesions macroscopically disappeared, and in the other patient, the 
      supraclavicular lymph node disappeared while the other measurable lesions 
      remained stable. CONCLUSIONS: All the patients showed some evidence suggesting 
      the presence of a graft-versus-tumor effect for colorectal cancer, which should 
      be confirmed in a future prospective trial.
FAU - Kojima, Rie
AU  - Kojima R
AD  - Hematopoietic Stem Cell Transplant Unit, the National Cancer Center Hospital, 
      Tokyo, Japan.
FAU - Kami, Masahiro
AU  - Kami M
FAU - Hori, Akiko
AU  - Hori A
FAU - Murashige, Naoko
AU  - Murashige N
FAU - Ohnishi, Mutsuko
AU  - Ohnishi M
FAU - Kim, Sung-Won
AU  - Kim SW
FAU - Hamaki, Tamae
AU  - Hamaki T
FAU - Kishi, Yukiko
AU  - Kishi Y
FAU - Tsutsumi, Yutaka
AU  - Tsutsumi Y
FAU - Masauzi, Nobuo
AU  - Masauzi N
FAU - Heike, Yuji
AU  - Heike Y
FAU - Mori, Shin-Ichiro
AU  - Mori S
FAU - Kobayashi, Kazuhiko
AU  - Kobayashi K
FAU - Masuo, Shigeru
AU  - Masuo S
FAU - Tanosaki, Ryuji
AU  - Tanosaki R
FAU - Takaue, Yoichi
AU  - Takaue Y
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (CA-19-9 Antigen)
RN  - 0 (Carcinoembryonic Antigen)
SB  - IM
MH  - Adult
MH  - CA-19-9 Antigen/blood
MH  - Carcinoembryonic Antigen/blood
MH  - Colorectal Neoplasms/immunology/*pathology/*surgery/therapy
MH  - Female
MH  - Graft vs Host Disease/etiology
MH  - *Graft vs Tumor Effect
MH  - *Hematopoietic Stem Cell Transplantation/adverse effects
MH  - Humans
MH  - *Immunotherapy
MH  - Liver Neoplasms/secondary/surgery
MH  - Lung Neoplasms/secondary/surgery
MH  - Male
MH  - Middle Aged
MH  - Peritoneal Neoplasms/secondary/surgery
MH  - Time Factors
MH  - Tomography, X-Ray Computed
MH  - Transplantation, Homologous
MH  - Treatment Outcome
EDAT- 2004/12/23 09:00
MHDA- 2005/02/03 09:00
CRDT- 2004/12/23 09:00
PHST- 2004/12/23 09:00 [pubmed]
PHST- 2005/02/03 09:00 [medline]
PHST- 2004/12/23 09:00 [entrez]
AID - 00007890-200412270-00009 [pii]
AID - 10.1097/01.tp.0000146194.36297.4e [doi]
PST - ppublish
SO  - Transplantation. 2004 Dec 27;78(12):1740-6. doi: 
      10.1097/01.tp.0000146194.36297.4e.