PMID- 15614155
OWN - NLM
STAT- MEDLINE
DCOM- 20050131
LR  - 20190713
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 78
IP  - 12
DP  - 2004 Dec 27
TI  - Recipients who receive a human leukocyte antigen-B compatible cadaveric liver 
      allograft are at high risk of developing acute graft-versus-host disease.
PG  - 1809-11
AB  - Acute graft-versus-host disease (GvHD) is an uncommon but often fatal 
      complication after orthotopic liver transplantation (OLT). To determine whether 
      there is an association between human leukocyte antigen (HLA) matching and the 
      development of GvHD after cadaveric OLT, we undertook a retrospective, 
      single-center analysis of 412 consecutive adult recipients where HLA typing data 
      was available. Seven (1.7%) recipients developed acute GvHD, and six died from 
      their disease. Donor compatibility at HLA-B but not at HLA-A or -DR was 
      identified as a significant risk factor for the development of GvHD. Of 14 
      recipients with no HLA-B mismatches, 3 (21%) developed GvHD (odds ratio 27, 
      P<0.001). Conversely, of 262 recipients mismatched at both HLA-B loci, only 1 
      (0.4%) developed GvHD (odds ratio 0.09, P<0.01). Our findings suggest that 
      patients receiving a liver allograft with no HLA-B mismatched antigens are at 
      increased risk of developing GvHD.
FAU - Key, Tim
AU  - Key T
AD  - Tissue Typing Laboratory, University of Cambridge, Addenbrooke's Hospital, Hills 
      Road, Cambridge, UK.
FAU - Taylor, Craig J
AU  - Taylor CJ
FAU - Bradley, J Andrew
AU  - Bradley JA
FAU - Taylor, Anna L
AU  - Taylor AL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - Acute Disease
MH  - Aged
MH  - Female
MH  - Graft vs Host Disease/epidemiology/*etiology/mortality
MH  - HLA-B Antigens/*analysis
MH  - *Histocompatibility
MH  - Humans
MH  - Incidence
MH  - Liver Transplantation/*adverse effects/*immunology
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Transplantation, Homologous
EDAT- 2004/12/23 09:00
MHDA- 2005/02/03 09:00
CRDT- 2004/12/23 09:00
PHST- 2004/12/23 09:00 [pubmed]
PHST- 2005/02/03 09:00 [medline]
PHST- 2004/12/23 09:00 [entrez]
AID - 00007890-200412270-00018 [pii]
AID - 10.1097/01.tp.0000145523.08548.48 [doi]
PST - ppublish
SO  - Transplantation. 2004 Dec 27;78(12):1809-11. doi: 
      10.1097/01.tp.0000145523.08548.48.