PMID- 15618036
OWN - NLM
STAT- MEDLINE
DCOM- 20050825
LR  - 20061115
IS  - 0195-668X (Print)
IS  - 0195-668X (Linking)
VI  - 26
IP  - 7
DP  - 2005 Apr
TI  - Comparative assessment of right, left, and biventricular pacing in patients with 
      permanent atrial fibrillation.
PG  - 712-22
AB  - AIMS: Left ventricular (LV) and biventricular (BiV) pacing are potentially 
      superior to right ventricular (RV) apical pacing in patients undergoing 
      atrioventricular (AV) junction ablation and pacing for permanent atrial 
      fibrillation. METHODS AND RESULTS: Prospective randomized, single-blind, 3-month 
      crossover comparison between RV and LV pacing (phase 1) and between RV and BiV 
      pacing (phase 2) performed in 56 patients (70+/-8 years, 34 males) affected by 
      severely symptomatic permanent atrial fibrillation, uncontrolled ventricular 
      rate, or heart failure. Primary endpoints were quality of life and exercise 
      capacity. Compared with RV pacing, the Minnesota Living with Heart Failure 
      Questionnaire (LHFQ) score improved by 2 and 10% with LV and BiV pacing, 
      respectively, the effort dyspnoea item of the Specific Symptom Scale (SSS) 
      changed by 0 and 2%, the Karolinska score by 6 and 14% (P<0.05 for BiV), the New 
      York Heart Association (NYHA) class by 5 and 11% (P<0.05 for BiV), the 6-min 
      walked distance by 12 (+4%) and 4 m (+1%), and the ejection fraction by 5 and 5% 
      (P<0.05 for both). BiV pacing but not LV pacing was slightly better than RV 
      pacing in the subgroup of patients with preserved systolic function and absence 
      of native left bundle branch block. Compared with pre-ablation measures, the 
      Minnesota LHFQ score improved by 37, 39, and 49% during RV, LV, and BiV pacing, 
      respectively, the effort dyspnoea item of the SSS by 25, 25, and 39%, the 
      Karolinska score by 39, 42, and 54%, the NYHA class by 21, 25, and 30%, the 6-min 
      walking distance by 35 (12%), 47 (16%), and 51 m (19%) and the ejection fraction 
      by 5, 10, and 10% (all differences P<0.05). CONCLUSIONS: Rhythm regularization 
      achieved with AV-junction ablation improved quality of life and exercise capacity 
      with all modes of pacing. LV and BiV pacing provided modest or no additional 
      favourable effect compared with RV pacing.
FAU - Brignole, M
AU  - Brignole M
AD  - Department of Cardiology, Ospedali del Tigullio, Via don Bobbio, 16033 Lavagna, 
      Italy. mbrignole@asl4.liguria.it
FAU - Gammage, M
AU  - Gammage M
FAU - Puggioni, E
AU  - Puggioni E
FAU - Alboni, P
AU  - Alboni P
FAU - Raviele, A
AU  - Raviele A
FAU - Sutton, R
AU  - Sutton R
FAU - Vardas, P
AU  - Vardas P
FAU - Bongiorni, M G
AU  - Bongiorni MG
FAU - Bergfeldt, L
AU  - Bergfeldt L
FAU - Menozzi, C
AU  - Menozzi C
FAU - Musso, G
AU  - Musso G
CN  - Optimal Pacing SITE (OPSITE) Study Investigators
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20041220
PL  - England
TA  - Eur Heart J
JT  - European heart journal
JID - 8006263
SB  - IM
CIN - Eur Heart J. 2005 Apr;26(7):637-8. PMID: 15755752
MH  - Aged
MH  - Atrial Fibrillation/*therapy
MH  - Cardiac Pacing, Artificial/*methods
MH  - Cross-Over Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Prospective Studies
MH  - Single-Blind Method
MH  - Treatment Outcome
EDAT- 2004/12/25 09:00
MHDA- 2005/08/27 09:00
CRDT- 2004/12/25 09:00
PHST- 2004/12/25 09:00 [pubmed]
PHST- 2005/08/27 09:00 [medline]
PHST- 2004/12/25 09:00 [entrez]
AID - ehi069 [pii]
AID - 10.1093/eurheartj/ehi069 [doi]
PST - ppublish
SO  - Eur Heart J. 2005 Apr;26(7):712-22. doi: 10.1093/eurheartj/ehi069. Epub 2004 Dec 
      20.