PMID- 15618130
OWN - NLM
STAT- MEDLINE
DCOM- 20050203
LR  - 20190608
IS  - 1535-3702 (Print)
IS  - 1535-3699 (Linking)
VI  - 230
IP  - 1
DP  - 2005 Jan
TI  - Anti-allergic effects of Artemisia iwayomogi on mast cell-mediated allergy model.
PG  - 82-8
AB  - The discovery of drugs for the treatment of allergic disease is an important 
      subject in human health. The Artemisia iwayomogi (Compositae) (AIE) has been used 
      as a traditional medicine in Korea and is known to have an anti-inflammatory 
      effect. However, its specific mechanism of action is still unknown. In this 
      report, we investigated the effect of AIE on the mast cell-mediated allergy model 
      and studied the possible mechanism of action. AIE inhibited compound 
      48/80-induced systemic reactions and plasma histamine release in mice. AIE 
      decreased immunoglobulin E (IgE)-mediated local allergic reaction, passive 
      cutaneous anaphylaxis (PCA) reaction. AIE dose dependently attenuated histamine 
      release from rat peritoneal mast cells activated by compound 48/80 or IgE. AIE 
      decreased the compound 48/80-induced intracellular Ca(2+). Furthermore, AIE 
      decreased the phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore 
      A23187-stimulated tumor necrosis factor-alpha and interleukin-6 gene expression 
      and production in human mast cells. The inhibitory effect of AIE on the 
      proinflammatory cytokine was p38 mitogen-activated protein kinase (MAPK) and 
      nuclear factor-kappaB (NF-kappaB) dependent. AIE attenuated PMA plus 
      A23187-induced degradation of IkappaBalpha and nuclear translocation of NF-kappaB 
      and specifically blocked activation of p38 MAPK but not that of c-jun N-terminal 
      kinase and extracellular signal-regulated kinase. Our findings provide evidence 
      that AIE inhibits mast cell-derived immediate-type allergic reactions and 
      involvement of intracellular Ca(2+), proinflammatory cytokines, p38 MAPK, and 
      NF-kappaB in these effects.
FAU - Kim, Sang-Hyun
AU  - Kim SH
AD  - College of Pharmacy, Woosuk University, Jeonju, Jeonbuk, 565-701, South Korea.
FAU - Choi, Cheol-Hee
AU  - Choi CH
FAU - Kim, Sang-Yong
AU  - Kim SY
FAU - Eun, Jae-Soon
AU  - Eun JS
FAU - Shin, Tae-Yong
AU  - Shin TY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Exp Biol Med (Maywood)
JT  - Experimental biology and medicine (Maywood, N.J.)
JID - 100973463
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (NF-kappa B)
RN  - 0 (Plant Extracts)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Anti-Allergic Agents/*pharmacology
MH  - Artemisia/*chemistry
MH  - Calcium/metabolism
MH  - Cell Line
MH  - Enzyme Activation
MH  - Histamine Release
MH  - Humans
MH  - Hypersensitivity/*drug therapy/enzymology/immunology/metabolism
MH  - Male
MH  - Mast Cells/*drug effects/enzymology/immunology/metabolism
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Mitogen-Activated Protein Kinases/metabolism
MH  - NF-kappa B/metabolism
MH  - Plant Extracts/pharmacology/*therapeutic use
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - p-Methoxy-N-methylphenethylamine/administration & dosage
EDAT- 2004/12/25 09:00
MHDA- 2005/02/04 09:00
CRDT- 2004/12/25 09:00
PHST- 2004/12/25 09:00 [pubmed]
PHST- 2005/02/04 09:00 [medline]
PHST- 2004/12/25 09:00 [entrez]
AID - 230/1/82 [pii]
AID - 10.1177/153537020523000111 [doi]
PST - ppublish
SO  - Exp Biol Med (Maywood). 2005 Jan;230(1):82-8. doi: 10.1177/153537020523000111.