PMID- 15618671
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20050329
LR  - 20191109
IS  - 1347-4367 (Print)
IS  - 1347-4367 (Linking)
VI  - 17
IP  - 3
DP  - 2002
TI  - A mutation in the flavin-containing monooxygenase 3 gene and its effects on 
      catalytic activity for N-oxidation of trimethylamine in vitro.
PG  - 207-13
AB  - To clarify the mutation of the flavin-containing monooxygenase (FMO) 3 gene 
      causing fish-odor syndrome, we analyzed the FMO3 gene of a Thai subject who 
      possibly suffered from fish-odor syndrome. A novel mutation, a single-base 
      substitution from G to A at the position of 265 (G265A), was identified in exon 
      3. The mutation caused an amino acid substitution from valine to isoleucine at 
      residue 58 (V58I). The mutated FMO3 protein with V58I exhibited the reduced 
      trimethylamine N-oxidase activity when it was expressed in E. coli. The 
      V(max)/K(m) value for the activity of the mutant-type FMO3 was about 5 times 
      lower than that for the wild-type FMO3.
FAU - Kubota, Megumi
AU  - Kubota M
AD  - Laboratory of Drug Metabolism, Division of Pharmacobio-dynamics, Graduate School 
      of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
FAU - Nakamoto, Yoko
AU  - Nakamoto Y
FAU - Nakayama, Kazuo
AU  - Nakayama K
FAU - Ujjin, Pailin
AU  - Ujjin P
FAU - Satarug, Soisungwan
AU  - Satarug S
FAU - Mushiroda, Taisei
AU  - Mushiroda T
FAU - Yokoi, Tsuyoshi
AU  - Yokoi T
FAU - Funayama, Masato
AU  - Funayama M
FAU - Kamataki, Tetsuya
AU  - Kamataki T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Drug Metab Pharmacokinet
JT  - Drug metabolism and pharmacokinetics
JID - 101164773
EDAT- 2004/12/25 09:00
MHDA- 2004/12/25 09:01
CRDT- 2004/12/25 09:00
PHST- 2004/12/25 09:00 [pubmed]
PHST- 2004/12/25 09:01 [medline]
PHST- 2004/12/25 09:00 [entrez]
AID - JST.JSTAGE/dmpk/17.207 [pii]
AID - 10.2133/dmpk.17.207 [doi]
PST - ppublish
SO  - Drug Metab Pharmacokinet. 2002;17(3):207-13. doi: 10.2133/dmpk.17.207.