PMID- 15619035
OWN - NLM
STAT- MEDLINE
DCOM- 20050915
LR  - 20060301
IS  - 1342-1751 (Print)
IS  - 1342-1751 (Linking)
VI  - 8
IP  - 4
DP  - 2004 Dec
TI  - Histologically confirmed superimposition of post-streptococcal acute 
      glomerulonephritis during IgA nephropathy.
PG  - 351-5
AB  - We describe a 39-year-old Japanese man with post-streptococcal acute 
      glomerulonephritis (PSAGN) super-imposed on long-term immunoglobulin A 
      nephropathy (IgA-N). The histological findings of the first renal biopsy, done at 
      21 years of age, revealed mild mesangial proliferative glomerulonephritis with 
      mesangial IgA deposition. Nineteen years later, acute nephritic syndrome with 
      hypocomplementemia and an increasing anti-streptolysin O (ASO) titer developed 2 
      weeks after the onset of an upper respiratory infection. A second renal biopsy 
      revealed severe segmental endocapillary proliferative and exudative 
      glomerulonephritis, with fibrocellular crescents in about 40% of the glomeruli. 
      Immunofluorescence showed that more C3 than IgA was deposited in the mesangium 
      and that the IgA deposits had decreased. Electron microscopy revealed "hump" 
      electron-dense deposits on the epithelial side of the glomerular basement 
      membrane. These features were consistent with PSAGN superimposed on IgA-N. After 
      2 weeks of observation, blood pressure, C3 level, and ASO titer had returned to 
      normal, although the persisting nephritic syndrome necessitated steroid therapy. 
      Six months after the onset of the acute nephritic syndrome, the patient remained 
      asymptomatic, except for microhematuria.
FAU - Horita, Yoshio
AU  - Horita Y
AD  - Department of Internal Medicine, Nagasaki Municipal Medical Center, 20-5 
      Fuchi-machi, Nagasaki, 852-8012 Japan. y-horita@h8.dion.ne.jp
FAU - Tadokoro, Masato
AU  - Tadokoro M
FAU - Taura, Koichi
AU  - Taura K
FAU - Suyama, Naofumi
AU  - Suyama N
FAU - Taguchi, Takashi
AU  - Taguchi T
FAU - Miyazaki, Masanobu
AU  - Miyazaki M
FAU - Kohno, Shigeru
AU  - Kohno S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Japan
TA  - Clin Exp Nephrol
JT  - Clinical and experimental nephrology
JID - 9709923
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Biopsy
MH  - Glomerulonephritis/diagnosis/*etiology/pathology
MH  - Glomerulonephritis, IGA/pathology/*physiopathology
MH  - Humans
MH  - Kidney Glomerulus/cytology/metabolism/pathology
MH  - Male
MH  - Streptococcal Infections/*complications
EDAT- 2004/12/25 09:00
MHDA- 2005/09/16 09:00
CRDT- 2004/12/25 09:00
PHST- 2004/01/26 00:00 [received]
PHST- 2004/07/22 00:00 [accepted]
PHST- 2004/12/25 09:00 [pubmed]
PHST- 2005/09/16 09:00 [medline]
PHST- 2004/12/25 09:00 [entrez]
AID - 10.1007/s10157-004-0311-1 [doi]
PST - ppublish
SO  - Clin Exp Nephrol. 2004 Dec;8(4):351-5. doi: 10.1007/s10157-004-0311-1.