PMID- 15621833
OWN - NLM
STAT- MEDLINE
DCOM- 20050621
LR  - 20190116
IS  - 1042-8194 (Print)
IS  - 1026-8022 (Linking)
VI  - 46
IP  - 3
DP  - 2005 Mar
TI  - Chromosomal aberrations and CD38 expression in two siblings with B-cell chronic 
      lymphocytic leukemia: a report of two siblings.
PG  - 421-3
AB  - In this study our purpose was to define chromosomal aberrations and CD38 
      expression in male siblings 69 and 66-years-old with B-cell chronic lymphocytic 
      leukemia (B-CLL). Cells from peripheral blood were analysed by comparative 
      genomic hybridization (CGH) and fluorescence in situ hybridization (FISH). The 
      alteration detectable by CGH was the over-representation of the Y chromosome in 
      both samples. Interphase FISH were performed using locus (13q14 and 17p53) and 
      centromere (chromosome 12, 17 and Y) specific DNA probes. One brother (patient 1, 
      69 years of age) showed deletion of the 13q14 region, this alteration was 
      associated with low CD38 expression, both predicting a favourable prognosis. 
      However, the younger patient's (patient 2, 66 years of age) cells expressed CD38 
      in high percent, which is considered as an indicator of poor prognosis, and 
      deletion of the 13q14 was not seen. Other, relatively frequent chromosomal 
      alterations including trisomy 12 and deletion of 17p53 were not present in any of 
      the samples. The cytogenetic findings and the CD38 expression are in concordance 
      with the clinico-pathological data of the siblings. Thus, we found the 
      variability of these parameters described in B-CLL even in the familial form of 
      the disease.
FAU - Mehes, Leonora
AU  - Mehes L
AD  - 2nd Department of Medicine, Faculty of Medicine, Medical and Health Science 
      Center, University of Debrecen, Hungary. mehes.leonora@yahoo.com
FAU - Balazs, Margit
AU  - Balazs M
FAU - Rejto, Laszlo
AU  - Rejto L
FAU - Telek, Bela
AU  - Telek B
FAU - Kiss, Attila
AU  - Kiss A
FAU - Udvardy, Miklos
AU  - Udvardy M
LA  - eng
PT  - Case Reports
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (Antigens, CD)
RN  - 0 (Membrane Glycoproteins)
RN  - EC 3.2.2.5 (ADP-ribosyl Cyclase)
RN  - EC 3.2.2.5 (CD38 protein, human)
RN  - EC 3.2.2.6 (ADP-ribosyl Cyclase 1)
SB  - IM
MH  - ADP-ribosyl Cyclase/*biosynthesis
MH  - ADP-ribosyl Cyclase 1
MH  - Aged
MH  - Antigens, CD/*biosynthesis
MH  - *Chromosome Aberrations
MH  - Genotype
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/classification/*diagnosis/genetics
MH  - Male
MH  - Membrane Glycoproteins
MH  - Nucleic Acid Hybridization
MH  - Phenotype
MH  - Siblings
EDAT- 2004/12/29 09:00
MHDA- 2005/06/23 09:00
CRDT- 2004/12/29 09:00
PHST- 2004/12/29 09:00 [pubmed]
PHST- 2005/06/23 09:00 [medline]
PHST- 2004/12/29 09:00 [entrez]
AID - H4UWPH15XRHXGGCJ [pii]
AID - 10.1080/10428190400015808 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2005 Mar;46(3):421-3. doi: 10.1080/10428190400015808.