PMID- 15624500
OWN - NLM
STAT- MEDLINE
DCOM- 20050215
LR  - 20151119
IS  - 0047-1860 (Print)
IS  - 0047-1860 (Linking)
VI  - 52
IP  - 10
DP  - 2004 Oct
TI  - [Topics on immunological tests for rheumatoid arthritis].
PG  - 836-43
AB  - To prevent joint destruction, it is important to diagnose RA early and to 
      speculate the prognosis. Several new laboratory tests have been developed for 
      this purpose. In addition to rheumatoid factor (RF), IgG-RF, anti-agalactosyl IgG 
      antibodies (CARF), and matrix metalloproteinase 3 (MMP-3) have become available 
      as diagnostic tests for RA. Among them, anti-cyclic citrullinated peptide 
      antibodies (anti-CCP antibodies) have the sensitivity and specificity of 81.0% 
      and 92.4%, respectively, which are superior to other laboratory tests by ROC 
      analysis. Moreover, the specificity of anti-CCP antibodies to diagnose early RA 
      was much higher than that of RF, although the sensitivity of CARF was slightly 
      high compared with that of RF. In contrast, MMP-3 is thought to be an evaluative 
      test for the activity of RA because a significant correlation was found between 
      MMP-3 and CRP, but MMP-3 has a possibility as a prognostic test to know the joint 
      damage of RA. We have shown that the progression of joint damage (Sharp score) 
      was faster in MMP-3-positive patients than negative patients. Anti-CCP antibodies 
      was also reported to associate with the progression of joint damage and may be 
      used also as a prognostic test. We next examined how efficiently was the 
      diagnosis of RA made by combining these laboratory tests. Although anti-CCP 
      antibodies are highly specific to RA, the specificity of RF was not so high but 
      became up to 92% when combined with MMP-3. In order to diagnose RA efficiently, 
      we may firstly examine RF, next MMP-3 if RF is positive, and anti-CCP antibodies 
      if RF is negative.
FAU - Kumagai, Shunichi
AU  - Kumagai S
AD  - Medical Bioinformatics, Kobe University Graduate School of Medicine, Kobe 
      650-0017.
FAU - Nishimura, Kunihiro
AU  - Nishimura K
FAU - Hayashi, Nobuhide
AU  - Hayashi N
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Rinsho Byori
JT  - Rinsho byori. The Japanese journal of clinical pathology
JID - 2984781R
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Peptides, Cyclic)
RN  - 0 (agalactosyl IGG)
RN  - 0 (cyclic citrullinated peptide)
RN  - 9009-79-4 (Rheumatoid Factor)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Arthritis, Rheumatoid/*diagnosis
MH  - Autoantibodies/*blood
MH  - Biomarkers/blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Humans
MH  - Immunoglobulin G/blood
MH  - *Immunologic Tests
MH  - Matrix Metalloproteinase 3/blood
MH  - Peptides, Cyclic/*immunology
MH  - Rheumatoid Factor/blood
MH  - Sensitivity and Specificity
RF  - 29
EDAT- 2004/12/31 09:00
MHDA- 2005/02/16 09:00
CRDT- 2004/12/31 09:00
PHST- 2004/12/31 09:00 [pubmed]
PHST- 2005/02/16 09:00 [medline]
PHST- 2004/12/31 09:00 [entrez]
PST - ppublish
SO  - Rinsho Byori. 2004 Oct;52(10):836-43.