PMID- 15626888
OWN - NLM
STAT- MEDLINE
DCOM- 20050131
LR  - 20221207
IS  - 1078-0998 (Print)
IS  - 1078-0998 (Linking)
VI  - 10
IP  - 6
DP  - 2004 Nov
TI  - IBD1 and IBD3 determine location of Crohn's disease in the Spanish population.
PG  - 715-22
AB  - BACKGROUND: Crohn's disease is a heterogeneous disease from both genetic and 
      clinical points of view. AIMS: To look for associations between distinct genetic 
      polymorphisms and clinical subgroups of the disease. SUBJECTS: A total of 210 
      patients and 343 healthy control subjects, all adult, unrelated, white, Spanish 
      individuals. METHODS: DNA was purified from peripheral blood samples and was 
      typed by sequence-specific oligonucleotide polymerase chain reaction (PCR) method 
      for human leukocyte antigen (HLA)-DRB1 alleles (IBD3) and by allele-specific PCR 
      for NOD2/CARD15 (IBD1) polymorphisms. RESULTS: NOD2/CARD15 mutations and 
      HLA-DRB1*07 confer susceptibility only to the ileal location of the disease, 
      whereas HLA-DRB1*0103 is associated only with the colonic location of the 
      disease. The IBD3 effect was overshadowed by IBD1 mutations when present. 
      CONCLUSION: The studied genetic polymorphisms of Crohn's disease basically 
      determine the location of the disease and, only secondarily, the clinical form of 
      the disease. This appears to be true for both inflammatory bowel diseases as 
      HLA-DRB1*0103 is associated both with colonic Crohn's disease and ulcerative 
      colitis.
FAU - Fernandez, Laura
AU  - Fernandez L
AD  - Department of Clinical Immunology, Hospital Clinico San Carlos, Madrid, Spain.
FAU - Mendoza, Juan L
AU  - Mendoza JL
FAU - Martinez, Alfonso
AU  - Martinez A
FAU - Urcelay, Elena
AU  - Urcelay E
FAU - Fernandez-Arquero, Miguel
AU  - Fernandez-Arquero M
FAU - Garcia-Paredes, Julio
AU  - Garcia-Paredes J
FAU - Pena, A Salvador
AU  - Pena AS
FAU - Diaz-Rubio, Manuel
AU  - Diaz-Rubio M
FAU - de la Concha, Emilio G
AU  - de la Concha EG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Inflamm Bowel Dis
JT  - Inflammatory bowel diseases
JID - 9508162
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (NOD2 protein, human)
RN  - 0 (Nod2 Signaling Adaptor Protein)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Crohn Disease/*genetics
MH  - DNA/analysis/blood
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Infant
MH  - Intracellular Signaling Peptides and Proteins/genetics
MH  - Male
MH  - Nod2 Signaling Adaptor Protein
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic
MH  - Spain
MH  - White People/genetics
EDAT- 2005/01/01 09:00
MHDA- 2005/02/03 09:00
CRDT- 2005/01/01 09:00
PHST- 2005/01/01 09:00 [pubmed]
PHST- 2005/02/03 09:00 [medline]
PHST- 2005/01/01 09:00 [entrez]
AID - 00054725-200411000-00004 [pii]
AID - 10.1097/00054725-200411000-00004 [doi]
PST - ppublish
SO  - Inflamm Bowel Dis. 2004 Nov;10(6):715-22. doi: 10.1097/00054725-200411000-00004.