PMID- 15629059
OWN - NLM
STAT- MEDLINE
DCOM- 20050218
LR  - 20221207
IS  - 1672-0229 (Print)
IS  - 2210-3244 (Electronic)
IS  - 1672-0229 (Linking)
VI  - 1
IP  - 4
DP  - 2003 Nov
TI  - HLA-A gene polymorphism defined by high-resolution sequence-based typing in 161 
      Northern Chinese Han people.
PG  - 304-9
AB  - Human leukocyte antigen (HLA) system is the most polymorphic region known in the 
      human genome. In the present study, we analyzed for the first time the HLA-A gene 
      polymorphisms defined by the high-resolution typing methods-sequence-based typing 
      (SBT) in 161 Northern Chinese Han people. A total of 74 different HLA-A gene 
      types and 36 alleles were detected. The most frequent alleles were A*110101 
      (GF=0.2360), A*24020101 (GF=0.1646), and A*020101 (GF=0.1553); followed by A*3303 
      (GF=0.1180), A*3001 (GF=0.0590), and A*310102 (GF=0.0404). The frequencies of 
      following alleles, A*0203, A*0205, A*0206, A*0207, A*030101, A*2423, A*2601, 
      A*3201, and A*3301, are all higher than 0.0093. The homozygous alleles include 
      A*020101, A*110101, A*24020101 and A*310102. Heterozygosity (H), polymorphism 
      information content (PIC), discrimination power (DP) and probability of paternity 
      exclusion (PPE) of HLA-A in the samples were calculated and their values were 
      0.8705, 0.8491, 0.6014, and 0.9475, respectively. These results by SBT analysis 
      of HLA-A polymorphism in Northern Chinese Han population, especially the allele 
      subtypes character, will be of great interest for clinical transplantation, 
      disease-associated study and forensic identification. Implementation of 
      high-resolution typing methods allows a significantly wider spectrum of HLA 
      variation including rare alleles. This spectrum will further be extensively 
      utilized in many fields.
FAU - Yan, Chunxia
AU  - Yan C
AD  - The State Laboratory of the Ministry of Health for Forensic Sciences, Xi'an 
      710061, China.
FAU - Wang, Ruilin
AU  - Wang R
FAU - Li, Jingxiang
AU  - Li J
FAU - Deng, Yajun
AU  - Deng Y
FAU - Wu, Dongying
AU  - Wu D
FAU - Zhang, Hongbo
AU  - Zhang H
FAU - Zhang, Hongxing
AU  - Zhang H
FAU - Wang, Lidong
AU  - Wang L
FAU - Zhang, Chunrong
AU  - Zhang C
FAU - Sun, Haiyan
AU  - Sun H
FAU - Zhang, Xiuqing
AU  - Zhang X
FAU - Wang, Jian
AU  - Wang J
FAU - Yang, Huanming
AU  - Yang H
FAU - Li, Shengbin
AU  - Li S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Genomics Proteomics Bioinformatics
JT  - Genomics, proteomics & bioinformatics
JID - 101197608
RN  - 0 (HLA-A Antigens)
SB  - IM
MH  - Alleles
MH  - Asian People/*genetics
MH  - China
MH  - DNA Mutational Analysis/*methods
MH  - Gene Frequency
MH  - Genotype
MH  - HLA-A Antigens/blood/*genetics
MH  - Humans
MH  - Polymorphism, Genetic/*genetics
MH  - Sensitivity and Specificity
MH  - Sequence Analysis, DNA
MH  - Serology
PMC - PMC5172246
EDAT- 2005/01/05 09:00
MHDA- 2005/02/19 09:00
PMCR- 2016/11/28
CRDT- 2005/01/05 09:00
PHST- 2005/01/05 09:00 [pubmed]
PHST- 2005/02/19 09:00 [medline]
PHST- 2005/01/05 09:00 [entrez]
PHST- 2016/11/28 00:00 [pmc-release]
AID - S1672-0229(03)01036-2 [pii]
AID - 10.1016/s1672-0229(03)01036-2 [doi]
PST - ppublish
SO  - Genomics Proteomics Bioinformatics. 2003 Nov;1(4):304-9. doi: 
      10.1016/s1672-0229(03)01036-2.