PMID- 15630668
OWN - NLM
STAT- MEDLINE
DCOM- 20050512
LR  - 20201209
IS  - 0094-6176 (Print)
IS  - 0094-6176 (Linking)
VI  - 30
IP  - 6
DP  - 2004 Dec
TI  - Current role of antithrombotic agents in the treatment of acute coronary 
      syndromes.
PG  - 627-32
AB  - Acute coronary syndromes (ACS) refer to a spectrum of myocardial ischemic 
      disorders characterized by atherothrombotic plaque disruption. The management of 
      ACS presents a challenge to the cardiologist because treatment strategies 
      continue to evolve. Thrombin plays a pivotal role in thrombus formation, 
      converting fibrinogen to fibrin, activating platelets, and recruiting additional 
      platelets into the platelet-rich thrombus. In addition to unfractionated heparin 
      (UFH), newer antithrombotic agents are now available and have significantly 
      changed contemporary clinical practice. Low-molecular-weight heparins (LMWHs) has 
      been shown to be superior to UFH in several trials. Direct thrombin inhibitors 
      (DTIs) have been shown to be effective in patients undergoing elective coronary 
      interventions and are being evaluated in patients with ACS. We review two classes 
      of antithrombotic drugs, the LMWHs and the DTIs and discuss their current roles 
      in the management of patients with ACS.
FAU - Mukherjee, Debabrata
AU  - Mukherjee D
AD  - Tyler Gill Professor of Interventional Cardiology, Division of Vascular Medicine, 
      Gill Heart Institute, University of Kentucky, Lexington 40536-0200, USA. 
      Mukherjee@uky.edu
FAU - Bates, Eric R
AU  - Bates ER
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Semin Thromb Hemost
JT  - Seminars in thrombosis and hemostasis
JID - 0431155
RN  - 0 (Anticoagulants)
RN  - 0 (Enoxaparin)
RN  - 0 (Fibrinolytic Agents)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 0 (Hirudins)
RN  - 0 (Peptide Fragments)
RN  - 0 (Pipecolic Acids)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Sulfonamides)
RN  - 94ZLA3W45F (Arginine)
RN  - EC 3.4.21.5 (Thrombin)
RN  - IY90U61Z3S (argatroban)
RN  - TN9BEX005G (bivalirudin)
SB  - IM
CIN - Semin Thromb Hemost. 2005 Apr;31(2):248. PMID: 15852228
MH  - Aged
MH  - Anticoagulants/therapeutic use
MH  - Arginine/analogs & derivatives
MH  - Blood Platelets/drug effects
MH  - Clinical Trials as Topic
MH  - Enoxaparin/therapeutic use
MH  - Fibrinolytic Agents/*therapeutic use
MH  - Heparin, Low-Molecular-Weight/therapeutic use
MH  - Hirudins/*analogs & derivatives/metabolism/pharmacology
MH  - Humans
MH  - Middle Aged
MH  - Models, Biological
MH  - Myocardial Infarction/*drug therapy
MH  - Peptide Fragments/pharmacology/therapeutic use
MH  - Pipecolic Acids/therapeutic use
MH  - Recombinant Proteins/pharmacology/therapeutic use
MH  - Risk
MH  - Sulfonamides
MH  - Thrombin/antagonists & inhibitors
RF  - 23
EDAT- 2005/01/05 09:00
MHDA- 2005/05/13 09:00
CRDT- 2005/01/05 09:00
PHST- 2005/01/05 09:00 [pubmed]
PHST- 2005/05/13 09:00 [medline]
PHST- 2005/01/05 09:00 [entrez]
AID - 10.1055/s-2004-861504 [doi]
PST - ppublish
SO  - Semin Thromb Hemost. 2004 Dec;30(6):627-32. doi: 10.1055/s-2004-861504.