PMID- 15630741
OWN - NLM
STAT- MEDLINE
DCOM- 20050414
LR  - 20220408
IS  - 0315-162X (Print)
IS  - 0315-162X (Linking)
VI  - 32
IP  - 1
DP  - 2005 Jan
TI  - Minimal clinically important differences of the childhood health assessment 
      questionnaire.
PG  - 150-61
AB  - OBJECTIVE: The Childhood Health Assessment Questionnaire (CHAQ) is a commonly 
      used measure of disability and physical function for children with juvenile 
      rheumatoid arthritis (JRA), whose scores range between 0 (no disability) and 3 
      (very severe disability), with a smallest potential difference in the CHAQ score 
      of individuals at 0.125. We estimated minimal clinically important differences 
      (MCID) of the CHAQ for worsening and improvement that were actually experienced 
      by children with JRA using patient, parent, and clinical perspectives. METHODS: 
      Changes in CHAQ scores were calculated for parent (n = 92) and patient ratings 
      (children age > or = 8 yrs only; n = 67) between subsequent clinic visits. 
      Changes in patient well being and disease activity and the occurrence of flare or 
      important improvement between visits served as external standards for the MCID. 
      MCID were defined as the median changes of the CHAQ scores of individual patients 
      who had a minimal important improvement or worsening between visits. RESULTS: The 
      median change in CHAQ scores of patients who rated themselves or were rated by 
      others as unchanged was often 0. Depending on the external standard used, the 
      MCID for improvement of the CHAQ was -0.188 at most, while the MCID for worsening 
      was at most +0.125. CONCLUSION: The MCID of the CHAQ for both improvement and 
      worsening are often at or close to the level of the smallest potential 
      difference, suggesting that the CHAQ is relatively insensitive to important short 
      term changes in children with JRA. This may warrant a change in the calculation 
      of the global CHAQ score, or the development of more sensitive functional 
      measures.
FAU - Brunner, Hermine I
AU  - Brunner HI
AD  - Division of Rheumatology, Cincinnati Children's Hospital Medical Center, 
      Cincinnati, Ohio 45229-3039, USA. hermine.brunner@cchmc.org
FAU - Klein-Gitelman, Marisa S
AU  - Klein-Gitelman MS
FAU - Miller, Michael J
AU  - Miller MJ
FAU - Barron, Andrea
AU  - Barron A
FAU - Baldwin, Nicole
AU  - Baldwin N
FAU - Trombley, Michael
AU  - Trombley M
FAU - Johnson, Anne L
AU  - Johnson AL
FAU - Kress, Angie
AU  - Kress A
FAU - Lovell, Daniel J
AU  - Lovell DJ
FAU - Giannini, Edward H
AU  - Giannini EH
LA  - eng
GR  - P60 AR47784/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
SB  - IM
MH  - Adolescent
MH  - Arthritis, Rheumatoid/*diagnosis/physiopathology
MH  - Child
MH  - Child, Preschool
MH  - *Disability Evaluation
MH  - *Health Status
MH  - *Health Status Indicators
MH  - Humans
MH  - Infant
MH  - Prognosis
MH  - *Surveys and Questionnaires
MH  - Treatment Outcome
EDAT- 2005/01/05 09:00
MHDA- 2005/04/15 09:00
CRDT- 2005/01/05 09:00
PHST- 2005/01/05 09:00 [pubmed]
PHST- 2005/04/15 09:00 [medline]
PHST- 2005/01/05 09:00 [entrez]
AID - 0315162X-32-150 [pii]
PST - ppublish
SO  - J Rheumatol. 2005 Jan;32(1):150-61.