PMID- 15631512
OWN - NLM
STAT- MEDLINE
DCOM- 20050302
LR  - 20121115
IS  - 0021-8561 (Print)
IS  - 0021-8561 (Linking)
VI  - 53
IP  - 1
DP  - 2005 Jan 12
TI  - Antioxidative effect of kaempferol and its equimolar mixture with phenyltin 
      compounds on UV-irradiated liposome membranes.
PG  - 76-83
AB  - The work investigates the possibility of the protective action of kaempferol on 
      phosphatidylcholine liposome membranes exposed to the pro-oxidative action of 
      diphenyltin dichloride (DPhT) and triphenyltin chloride (TPhT) induced by UV 
      radiation (lambda = 253.7 nm). The concentrations of kaempferol and its equimolar 
      mixtures with DPhT and TPhT were determined so that they induce 50% inhibition in 
      oxidation of liposomes irradiated with UV. They are 11.6, 10.0, and 4.5 microM/L, 
      which constitute the following sequence of antioxidative activity: 
      kaempferol/triphenyltin > kaempferol/diphenyltin > kaempferol. This relationship 
      is confirmed by the results on the antiradical ability of kaempferol and its 
      mixtures with DPhT and TPhT toward the free radical 
      2,2-diphenyl-1-picrylhydrazyl. Similar sequences obtained in both studies suggest 
      a possible mechanism of the antiradical action of the mixtures as free radical 
      scavengers. Kaempferol's ability, then documented, to form complexes with 
      phenyltins indicates (a) a possible way to liquidate the peroxidation caused by 
      the free radical forms of phenyltins and (b) the stabilizing role of chelating in 
      the antioxidative action of the kaempferol/phenyltins. The differentiation in the 
      action of the compounds studied may, among others, result from different 
      localizations in the liposome membrane, which is indicated by the results of the 
      fluorometric studies.
FAU - Gabrielska, Janina
AU  - Gabrielska J
AD  - Department of Physics and Biophysics, Agricultural University, Norwida 25, 50-375 
      Wroclaw, Poland. jaga@ozi.ar.wroc.pl
FAU - Soczynska-Kordala, Monika
AU  - Soczynska-Kordala M
FAU - Przestalski, Stanislaw
AU  - Przestalski S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Antioxidants)
RN  - 0 (Kaempferols)
RN  - 0 (Liposomes)
RN  - 0 (Organotin Compounds)
RN  - 0 (Phosphatidylcholines)
RN  - 2406-68-0 (phenyltin)
RN  - 731P2LE49E (kaempferol)
SB  - IM
MH  - Antioxidants/*pharmacology
MH  - Drug Interactions
MH  - Kaempferols/chemistry/*pharmacology
MH  - Liposomes/*chemistry/radiation effects
MH  - Organotin Compounds/*pharmacology
MH  - Oxidation-Reduction
MH  - Phosphatidylcholines/chemistry
MH  - *Ultraviolet Rays
EDAT- 2005/01/06 09:00
MHDA- 2005/03/03 09:00
CRDT- 2005/01/06 09:00
PHST- 2005/01/06 09:00 [pubmed]
PHST- 2005/03/03 09:00 [medline]
PHST- 2005/01/06 09:00 [entrez]
AID - 10.1021/jf0401120 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2005 Jan 12;53(1):76-83. doi: 10.1021/jf0401120.