PMID- 15632006
OWN - NLM
STAT- MEDLINE
DCOM- 20050302
LR  - 20181113
IS  - 0002-9440 (Print)
IS  - 1525-2191 (Electronic)
IS  - 0002-9440 (Linking)
VI  - 166
IP  - 1
DP  - 2005 Jan
TI  - Expression of the T-cell transcription factors, GATA-3 and T-bet, in the 
      neoplastic cells of Hodgkin lymphomas.
PG  - 127-34
AB  - Since Hodgkin and Reed-Sternberg (HRS) cells of Hodgkin lymphoma (HL) generally 
      have immunoglobulin gene rearrangements, they are considered to be of B-cell 
      origin. One of the characteristics of HRS cells is a prominent production of 
      various cytokines and chemokines. Cytokine production is generally driven by 
      expression of T-cell transcription factors (TFs). Only limited information is 
      available on the expression of T-cell TFs in HL. Expression of four T-cell TFs 
      and the target cytokine spectrum of these TFs were analyzed in six HL and three 
      large B-cell lymphoma (LBCL) cell lines using quantitative PCR. ERM expression 
      was observed in all HL and LBCL cell lines. Out of HL cell lines, T-bet was 
      expressed in five, GATA-3 in four, and c-Maf in two cell lines. 
      Immunohistochemistry in HL tissues revealed that in 11 of 12 (92%) of the 
      classical HL cases HRS cells were GATA-3 and/or T-bet positive. In three of six 
      cases of nodular lymphocyte predominance type of HL, the neoplastic cells were 
      T-bet positive. Overall, the T-cell TF and cytokine profiles of the HL cell lines 
      showed a considerable degree of consistency. The expression of T-cell TFs may 
      explain the production of various cytokines by HL cell lines and HRS cells.
FAU - Atayar, Cigdem
AU  - Atayar C
AD  - Department of Pathology and Laboratory Medicine, Groningen University Medical 
      Center, Hanzeplein 1, P.O. Box 30.001 9700 RB Groningen, The Netherlands.
FAU - Poppema, Sibrand
AU  - Poppema S
FAU - Blokzijl, Tjasso
AU  - Blokzijl T
FAU - Harms, Geert
AU  - Harms G
FAU - Boot, Marcel
AU  - Boot M
FAU - van den Berg, Anke
AU  - van den Berg A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Pathol
JT  - The American journal of pathology
JID - 0370502
RN  - 0 (DNA Primers)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (GATA3 Transcription Factor)
RN  - 0 (GATA3 protein, human)
RN  - 0 (Interleukins)
RN  - 0 (T-Box Domain Proteins)
RN  - 0 (T-box transcription factor TBX21)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - B-Lymphocytes/pathology
MH  - Base Sequence
MH  - Cell Line, Tumor
MH  - DNA Primers
MH  - DNA-Binding Proteins/*genetics
MH  - GATA3 Transcription Factor
MH  - Gene Rearrangement, B-Lymphocyte/genetics
MH  - Hodgkin Disease/*genetics/pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Interleukins/genetics
MH  - Polymerase Chain Reaction
MH  - Reed-Sternberg Cells/pathology
MH  - T-Box Domain Proteins
MH  - T-Lymphocytes/pathology
MH  - Trans-Activators/*genetics
MH  - Transcription Factors/*genetics
PMC - PMC1602286
EDAT- 2005/01/06 09:00
MHDA- 2005/03/03 09:00
PMCR- 2005/07/01
CRDT- 2005/01/06 09:00
PHST- 2005/01/06 09:00 [pubmed]
PHST- 2005/03/03 09:00 [medline]
PHST- 2005/01/06 09:00 [entrez]
PHST- 2005/07/01 00:00 [pmc-release]
AID - S0002-9440(10)62238-9 [pii]
AID - 10.1016/S0002-9440(10)62238-9 [doi]
PST - ppublish
SO  - Am J Pathol. 2005 Jan;166(1):127-34. doi: 10.1016/S0002-9440(10)62238-9.