PMID- 15633455
OWN - NLM
STAT- MEDLINE
DCOM- 20050125
LR  - 20160512
IS  - 1447-6959 (Print)
IS  - 1447-073X (Linking)
VI  - 79
IP  - 4
DP  - 2004 Dec
TI  - Regulating filopodial dynamics through actin-depolymerizing factor/cofilin.
PG  - 173-83
AB  - The regulation of filopodial dynamics by neurotrophins and other guidance cues 
      plays an integral role in growth cone pathfinding. Filopodia are F-actin-based 
      structures that explore the local environment, generate forces and play a role in 
      growth cone translocation. Here, we review recent research showing that the 
      actin-depolymerizing factor (ADF)/cofilin family of proteins mediates changes in 
      the length and number of growth cone filopodia in response to brain-derived 
      neurotrophic factor (BDNF). Although inhibition of myosin contractility also 
      causes filopodial elongation, the elongation in response to BDNF does not occur 
      through a myosin-dependent pathway. Active ADF/cofilin increases the rate of 
      cycling between the monomer and polymer pools and is critical for the 
      BDNF-induced changes. Thus, we discuss potential mechanisms by which ADF/cofilin 
      may affect filopodial initiation and length change via its effects on F-actin 
      dynamics in light of past research on actin and myosin function in growth cones.
FAU - Fass, Joseph
AU  - Fass J
AD  - Department of Biochemistry and Molecular Biology, Colorado State University, Fort 
      Collins, Colorado 80523-1870, USA.
FAU - Gehler, Scott
AU  - Gehler S
FAU - Sarmiere, Patrick
AU  - Sarmiere P
FAU - Letourneau, Paul
AU  - Letourneau P
FAU - Bamburg, James R
AU  - Bamburg JR
LA  - eng
GR  - GM35126/GM/NIGMS NIH HHS/United States
GR  - HD19950/HD/NICHD NIH HHS/United States
GR  - NS40371/NS/NINDS NIH HHS/United States
GR  - NS43115/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - Japan
TA  - Anat Sci Int
JT  - Anatomical science international
JID - 101154140
RN  - 0 (Actin Depolymerizing Factors)
RN  - 0 (DSTN protein, human)
RN  - 0 (Destrin)
RN  - 0 (Dstn protein, mouse)
RN  - 0 (Microfilament Proteins)
RN  - 0 (Nerve Tissue Proteins)
SB  - IM
MH  - Actin Depolymerizing Factors
MH  - Animals
MH  - Cell Line, Tumor
MH  - Destrin
MH  - Growth Cones/*metabolism/ultrastructure
MH  - Humans
MH  - Mice
MH  - Microfilament Proteins/*metabolism/ultrastructure
MH  - Nerve Tissue Proteins/*metabolism/ultrastructure
RF  - 84
EDAT- 2005/01/07 09:00
MHDA- 2005/01/26 09:00
CRDT- 2005/01/07 09:00
PHST- 2005/01/07 09:00 [pubmed]
PHST- 2005/01/26 09:00 [medline]
PHST- 2005/01/07 09:00 [entrez]
AID - 10.1111/j.1447-073x.2004.00087.x [doi]
PST - ppublish
SO  - Anat Sci Int. 2004 Dec;79(4):173-83. doi: 10.1111/j.1447-073x.2004.00087.x.