PMID- 15633564
OWN - NLM
STAT- MEDLINE
DCOM- 20050324
LR  - 20091111
IS  - 0016-3813 (Print)
IS  - 0016-3813 (Linking)
VI  - 140
IP  - 6
DP  - 2004 Nov-Dec
TI  - [Secondary chromosomic changes in patients with chronic myeloid leukemia in a 
      reference hospital in Northeastern Mexico].
PG  - 589-92
AB  - INTRODUCTION: Our aim was to characterize the cytogenetic profile that displays a 
      certain phase of chronic myelogenous leukemia (CML), offering new directions for 
      investigation of the etiology to the molecular level. In Mexico, data does not 
      exist in this regard; thus, the objective of the present study was to determine 
      cytogenetic alterations in 56 Mestizo Mexican patients with LMC. DESIGN: 
      Cross-sectional study (diagnosis and stage) was carried out. MATERIALS AND 
      METHODS: samples of bone marrow of 56 patients with CML in different phases were 
      analyzed using G banding and fluorescence in situ hybridization (FISH) with DNA 
      probes for Philadelphia chromosome (Ph). RESULTS: 19% of patients in chronic 
      stage showed secondary chromosomal alterations in contrast with an observed 60% 
      in patients in accelerated stage. Most frequent alterations included trisomy 8 
      and 19, extra Ph chromosome, and isochromosome of the 17. CONCLUSIONS: We believe 
      this to be the first work that determines secondary chromosomal alterations in 
      Mexican racially mixed patients with LMC. These are in agreement with those 
      reported for other populations at the worldwide level.
FAU - Davila-Rodriguez, Martha I
AU  - Davila-Rodriguez MI
AD  - Division de Genetica, Centro de Investigacion Biomedica del Noreste, Instituto 
      Mexicano del Seguro Social, Monterrey, Mexico. marthadavila40@hotmail.com
FAU - Cerda-Flores, Ricardo M
AU  - Cerda-Flores RM
FAU - Leal-Garza, Carlos H
AU  - Leal-Garza CH
FAU - Arana-Trejo, Rosa M
AU  - Arana-Trejo RM
FAU - Baez-de la Fuente, Enrique
AU  - Baez-de la Fuente E
FAU - Cortes-Gutierrez, Elva I
AU  - Cortes-Gutierrez EI
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Alteraciones cromosomicas secundarias en pacientes con leucemia mieloide cronica, 
      en un hospital de referencia del noreste de Mexico.
PL  - Mexico
TA  - Gac Med Mex
JT  - Gaceta medica de Mexico
JID - 0010333
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Chromosome Aberrations
MH  - Cross-Sectional Studies
MH  - Female
MH  - Hospitals
MH  - Humans
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*genetics
MH  - Male
MH  - Mexico
MH  - Middle Aged
MH  - Referral and Consultation
EDAT- 2005/01/07 09:00
MHDA- 2005/03/25 09:00
CRDT- 2005/01/07 09:00
PHST- 2005/01/07 09:00 [pubmed]
PHST- 2005/03/25 09:00 [medline]
PHST- 2005/01/07 09:00 [entrez]
PST - ppublish
SO  - Gac Med Mex. 2004 Nov-Dec;140(6):589-92.