PMID- 1563501
OWN - NLM
STAT- MEDLINE
DCOM- 19920521
LR  - 20130523
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 5
IP  - 4
DP  - 1992 Apr
TI  - High prevalence of asthma in patients with bronchiectasis in Hong Kong.
PG  - 418-23
AB  - Eighty five Chinese patients with diffuse or localized bronchiectasis (non-cystic 
      fibrosis) were studied regarding the prevalence of asthma. Twenty three of the 85 
      had concomitant asthma, diagnosed by history and reversibility on lung function 
      testing either spontaneously or after bronchodilator. None fulfilled the 
      diagnostic criteria of allergic bronchopulmonary aspergillosis (ABPA). Asthma 
      preceded the onset of bronchiectasis in 13 patients and developed after long 
      duration of bronchiectasis in seven, while the temporal onset could not be 
      differentiated in three patients. Patients with both asthma and bronchiectasis 
      had inferior spirometric values, higher prevalence of bronchial 
      hyperresponsiveness to methacholine, higher prevalence of skin atopy, elevated 
      serum immunoglobulin E (IgE), and more sputum eosinophilia, compared with their 
      non-asthmatic counterparts. Possible mechanisms by which asthma and 
      bronchiectasis predispose to each other include asthmatic obstruction 
      contributing to development of bronchiectasis, and sensitization of airways with 
      increased lability due to microbial colonization of the ectatic bronchial tree.
FAU - Ip, M S
AU  - Ip MS
AD  - Dept of Medicine, University of Hong Kong, Queen Mary Hospital.
FAU - So, S Y
AU  - So SY
FAU - Lam, W K
AU  - Lam WK
FAU - Yam, L
AU  - Yam L
FAU - Liong, E
AU  - Liong E
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
SB  - IM
CIN - Eur Respir J. 1993 Jan;6(1):148-9. PMID: 8425588
MH  - Aspergillosis, Allergic Bronchopulmonary/diagnosis
MH  - Asthma/diagnosis/*epidemiology
MH  - Bronchiectasis/diagnosis/*epidemiology
MH  - Comorbidity
MH  - Female
MH  - Hong Kong/epidemiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Respiratory Function Tests
MH  - Skin Tests
EDAT- 1992/04/01 00:00
MHDA- 1992/04/01 00:01
CRDT- 1992/04/01 00:00
PHST- 1992/04/01 00:00 [pubmed]
PHST- 1992/04/01 00:01 [medline]
PHST- 1992/04/01 00:00 [entrez]
PST - ppublish
SO  - Eur Respir J. 1992 Apr;5(4):418-23.