PMID- 15635157
OWN - NLM
STAT- MEDLINE
DCOM- 20050520
LR  - 20220321
IS  - 0918-6158 (Print)
IS  - 0918-6158 (Linking)
VI  - 28
IP  - 1
DP  - 2005 Jan
TI  - Antiinflammatory activity of astilbic acid from Astilbe chinensis.
PG  - 24-6
AB  - This study examined the effect of astilbic acid 
      (3beta,6beta-dihydroxyolean-12-en-27-oic acid), which is a herbal medicine 
      isolated from Astilbe chinensis. Astilbic acid inhibited 5-lipoxygenase 
      (5-LOX)-dependent leukotriene C4 (LTC4) generation in bone marrow-derived mast 
      cells in a concentration-dependent manner with an IC50 value of 2.1 microM. In 
      addition, astilbic acid was tested in a rat passive cutaneous anaphylaxis (PCA) 
      reaction assay by administering 10 to 50 mg/kg i.p. Astilbic acid dose 
      dependently inhibited the PCA reaction, which was activated by anti-dinitrophenyl 
      (DNP) IgE. Furthermore, this compound inhibited mouse acetic acid-induced 
      writhing (47-62% inhibition at 0.4-50 mg/kg) after being administered orally, 
      while aspirin (200 mg/kg) showed 62% inhibition. These results suggest that 
      astilbic acid may be beneficial in regulating various inflammatory processes.
FAU - Moon, Tae Chul
AU  - Moon TC
AD  - College of Pharmacy, Yeungnam University, Gyongsan, Korea.
FAU - Lin, Chang Xiu
AU  - Lin CX
FAU - Lee, Joo Sang
AU  - Lee JS
FAU - Kim, Dong Seon
AU  - Kim DS
FAU - Bae, Kihwan
AU  - Bae K
FAU - Son, Kun Ho
AU  - Son KH
FAU - Kim, Hyun Pyo
AU  - Kim HP
FAU - Kang, Sam Sik
AU  - Kang SS
FAU - Son, Jong Keun
AU  - Son JK
FAU - Chang, Hyeun Wook
AU  - Chang HW
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (3beta,6beta-dihydroxyolean-12-en-27-oic acid)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Plant Extracts)
RN  - 0 (Plant Preparations)
RN  - 6SMK8R7TGJ (Oleanolic Acid)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/isolation & purification/*pharmacology
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Oleanolic Acid/*analogs & derivatives/isolation & purification/*pharmacology
MH  - Pain Measurement/*drug effects/methods
MH  - Plant Extracts/isolation & purification/pharmacology
MH  - Plant Preparations/isolation & purification/*pharmacology
MH  - Plant Roots
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2005/01/07 09:00
MHDA- 2005/05/21 09:00
CRDT- 2005/01/07 09:00
PHST- 2005/01/07 09:00 [pubmed]
PHST- 2005/05/21 09:00 [medline]
PHST- 2005/01/07 09:00 [entrez]
AID - JST.JSTAGE/bpb/28.24 [pii]
AID - 10.1248/bpb.28.24 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2005 Jan;28(1):24-6. doi: 10.1248/bpb.28.24.