PMID- 15637135
OWN - NLM
STAT- MEDLINE
DCOM- 20050513
LR  - 20240312
IS  - 0006-4971 (Print)
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Linking)
VI  - 105
IP  - 8
DP  - 2005 Apr 15
TI  - IgE- and IgE+Ag-mediated mast cell migration in an autocrine/paracrine fashion.
PG  - 3222-9
AB  - Mast cells are the major effector cells for immediate hypersensitivity and 
      chronic allergic reactions. These cells accumulate in mucosal tissues of allergic 
      reactions, where immunoglobulin E (IgE) is produced locally. Here we provide 
      evidence that, in addition to antigen that can attract IgE-bound mast cells, the 
      type of IgE molecules that efficiently activate mast cells can promote the 
      migration of mast cells in the absence of antigen. IgE- and IgE+Ag-mediated 
      migration involves an autocrine/paracrine secretion of soluble factors including 
      adenosine, leukotriene B4, and several chemokines. Their secretion depends on 2 
      tyrosine kinases, Lyn and Syk, and they are agonists of G-protein-coupled 
      receptors and signal through phosphatidylinositol 3-kinase gamma, leading to mast 
      cell migration. In mouse experiments, naive mast cells are attracted to IgE, and 
      IgE-sensitized mast cells are attracted to antigen. Therefore, IgE and antigen 
      are implicated in mast cell accumulation at allergic tissue sites with local high 
      IgE levels.
FAU - Kitaura, Jiro
AU  - Kitaura J
AD  - Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10 355 
      Science Center Dr, San Diego, CA 92121, USA.
FAU - Kinoshita, Tatsuya
AU  - Kinoshita T
FAU - Matsumoto, Masaaki
AU  - Matsumoto M
FAU - Chung, Shaun
AU  - Chung S
FAU - Kawakami, Yuko
AU  - Kawakami Y
FAU - Leitges, Michael
AU  - Leitges M
FAU - Wu, Dianqing
AU  - Wu D
FAU - Lowell, Clifford A
AU  - Lowell CA
FAU - Kawakami, Toshiaki
AU  - Kawakami T
LA  - eng
GR  - R01 AI038348/AI/NIAID NIH HHS/United States
GR  - R01 AI050209/AI/NIAID NIH HHS/United States
GR  - AI/GM38348/AI/NIAID NIH HHS/United States
GR  - AI50209/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20050106
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Antigens)
RN  - 0 (Chemokines)
RN  - 0 (Integrins)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (Receptors, IgE)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
SB  - IM
MH  - Animals
MH  - Antigens/immunology/pharmacology
MH  - Autocrine Communication/immunology
MH  - Cell Movement/*immunology
MH  - Chemokines/pharmacology
MH  - Immunoglobulin E/*immunology/pharmacology
MH  - Integrins/metabolism
MH  - Mast Cells/*cytology/*immunology/metabolism
MH  - Mice
MH  - Mice, Mutant Strains
MH  - Paracrine Communication/immunology
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Receptors, G-Protein-Coupled/metabolism
MH  - Receptors, IgE/metabolism
PMC - PMC1464406
MID - NIHMS8454
EDAT- 2005/01/08 09:00
MHDA- 2005/05/14 09:00
PMCR- 2006/05/22
CRDT- 2005/01/08 09:00
PHST- 2005/01/08 09:00 [pubmed]
PHST- 2005/05/14 09:00 [medline]
PHST- 2005/01/08 09:00 [entrez]
PHST- 2006/05/22 00:00 [pmc-release]
AID - S0006-4971(20)45617-4 [pii]
AID - 10.1182/blood-2004-11-4205 [doi]
PST - ppublish
SO  - Blood. 2005 Apr 15;105(8):3222-9. doi: 10.1182/blood-2004-11-4205. Epub 2005 Jan 
      6.