PMID- 15639647
OWN - NLM
STAT- MEDLINE
DCOM- 20050308
LR  - 20131121
IS  - 1521-6616 (Print)
IS  - 1521-6616 (Linking)
VI  - 114
IP  - 2
DP  - 2005 Feb
TI  - Intravenous immunoglobulin attenuates mesenteric ischemia-reperfusion injury.
PG  - 137-46
AB  - Intravenous immunoglobulin (IVIG) has been found useful in the treatment of 
      various clinical entities and its effect has been associated with inhibition of 
      complement-mediated tissue damage. The aim of this study was to determine the 
      ability of IVIG to protect against mesenteric ischemia-reperfusion (IR)-induced 
      local and remote injury. Rats received vehicle or IVIG (150-600 mg/kg) 5 min 
      prior to sham operation or 30 min of superior mesenteric artery occlusion, 
      followed by 5, 120, or 240 min of reperfusion. IVIG reduced IR-induced mucosal 
      injury without altering IR-induced increases in PMN infiltration or LTB(4) 
      generation. At 5 min post IR, the deposition of IgG and C3 in the lamina propria 
      and surface epithelial cells was attenuated by IVIG. The increased capillary 
      leak, evident at 240 min, was inhibited by IVIG and coincided with a reduction in 
      C3 deposition in lung tissue. The beneficial effects of IVIG may be related to 
      the ability to scavenge deleterious products.
FAU - Anderson, Jimie
AU  - Anderson J
AD  - Department of Surgery, Walter Reed Army Forest Glen, MD Institute of Research, 
      20910, USA.
FAU - Fleming, Sherry D
AU  - Fleming SD
FAU - Rehrig, Scott
AU  - Rehrig S
FAU - Tsokos, George C
AU  - Tsokos GC
FAU - Basta, Milan
AU  - Basta M
FAU - Shea-Donohue, Terez
AU  - Shea-Donohue T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Immunol
JT  - Clinical immunology (Orlando, Fla.)
JID - 100883537
RN  - 0 (Complement C3)
RN  - 0 (Complement C5)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 1HGW4DR56D (Leukotriene B4)
SB  - IM
MH  - Animals
MH  - Bronchoalveolar Lavage Fluid/immunology
MH  - Complement C3/immunology
MH  - Complement C5/immunology
MH  - Immunoglobulins, Intravenous/*pharmacology
MH  - Immunohistochemistry
MH  - Intestinal Mucosa/blood supply/immunology/pathology
MH  - Intestine, Small/*blood supply/immunology/pathology
MH  - Leukotriene B4/analysis/immunology
MH  - Lung/immunology
MH  - Male
MH  - Neutrophil Infiltration/immunology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reperfusion Injury/*drug therapy/immunology/pathology
MH  - Statistics, Nonparametric
EDAT- 2005/01/11 09:00
MHDA- 2005/03/09 09:00
CRDT- 2005/01/11 09:00
PHST- 2003/09/02 00:00 [received]
PHST- 2004/08/26 00:00 [accepted]
PHST- 2005/01/11 09:00 [pubmed]
PHST- 2005/03/09 09:00 [medline]
PHST- 2005/01/11 09:00 [entrez]
AID - S1521-6616(04)00276-1 [pii]
AID - 10.1016/j.clim.2004.08.018 [doi]
PST - ppublish
SO  - Clin Immunol. 2005 Feb;114(2):137-46. doi: 10.1016/j.clim.2004.08.018.