PMID- 15642199
OWN - NLM
STAT- MEDLINE
DCOM- 20060331
LR  - 20150313
VI  - 24
IP  - 1
DP  - 2005 Jan
TI  - [Chromosomal imbalance in primary lung squamous cell carcinoma and their 
      relationship with smoking].
PG  - 47-52
AB  - BACKGROUND & OBJECTIVE: Chromosomal imbalance plays an important role in 
      tumorigenesis of lung cancer, and may be influenced by different carcinogens. 
      This study was to examine chromosomal imbalance in primary lung squamous cell 
      carcinoma (LSCC), and their association with smoking. METHODS: Chromosomal gains 
      and losses in 39 specimens of LSCC were identified by comparative genomic 
      hybridization (CGH), the association between chromosomal imbalances in LSCC and 
      smoking was analyzed. RESULTS: The most frequent chromosomal gains of LSCC were 
      detected on chromosomal arms 3q (74.4%, 29/39), 5p (66.7%, 26/39), 1q (43.6%, 
      17/39), 8q (41.0%, 16/39), 12p (42.6%, 18/39), 2p (38.5%, 15/39), and 18p (33.3%, 
      13/39), with minimal amplified regions (MAR) at 3q26.2-29 (74.4%, 29/39), 
      5p14.3-15.3 (66.7%, 26/39), 1q41-44(41.0%, 16/39), 8q23 (41.0%, 16/39), 12p13 
      (41.0%, 16/39), and 18p11.2 (33.3%, 13/39)u high-copy-number amplification at 
      chromosomal arms 3q, and 5p were found in 15 (38.5%), and 6 (15.4%) patients. 
      Chromosomal losses mainly involved chromosomal arms 3p (56.4%, 22/39), 5q (53.8%, 
      21/39), 13q (51.3%, 20/39), 8p (46.1%, 18/39), 4p (43.6%, 17/39), 4q (43.6%, 
      17/39), 1p (41.0%, 16/39), 2q (38.5%, 15/39), 9q (35.9%, 14/39), 13p (35.9%, 
      14/39), 16p (35.9%, 14/39) ,6p (33.3%, 13/39), and 6q (30.7%, 12/39), with 
      minimal deleted regions (MDR) at 3p14.2-21.2 (51.3%, 20/39), 5q15-22 (51.3%, 
      20/39), 13q14.2-21.2 (48.7%, 19/39), 8p21.1-22 (43.6%, 17/39), 2q32 (35.9%, 
      14/39), and 16p12-13.1 (33.3%, 13/39). Amplification rates of chromosomal arms 
      3q, and 8q in smoking LSCC patients were significantly higher than those in 
      non-smoking LSCC patients (P=0.002,P=0.031). While high incidences of gains at 
      chromosomal arms 5p and 12p, and of losses at chromosomal arms 3p, 4q, and 5q 
      were the common feature of chromosomal changes of smoking and non-smoking LSCC 
      patients. CONCLUSION: 3q, 5p, 1q, 8q, 12p, 2p, 18p gains and 3p, 5q, 13q, 8p, 4p, 
      4q, 1p, 2q, 9q, 13p,16p, 6p, 6q loses might be involved in tumorigenesis and/or 
      progression of LSCC, smoking-induced lung cancer may be associated with 3q, 8q 
      gains.
FAU - Yan, Wen-Sheng
AU  - Yan WS
AD  - Research Department, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong 
      510-060, P.R. China.
FAU - Song, Lan-Ying
AU  - Song LY
FAU - Wei, Wei-Dong
AU  - Wei WD
FAU - Li, Ang
AU  - Li A
FAU - Liang, Qi-Wan
AU  - Liang QW
FAU - Liu, Ji-Hong
AU  - Liu JH
FAU - Fang, Yan
AU  - Fang Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Ai Zheng
JT  - Ai zheng = Aizheng = Chinese journal of cancer
JID - 9424852
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/etiology/*genetics
MH  - *Chromosome Aberrations
MH  - Chromosome Deletion
MH  - *Chromosomes, Human, Pair 3
MH  - Chromosomes, Human, Pair 8
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/etiology/*genetics
MH  - Male
MH  - Middle Aged
MH  - Nucleic Acid Hybridization
MH  - Smoking/*adverse effects
EDAT- 2005/01/12 09:00
MHDA- 2006/04/01 09:00
CRDT- 2005/01/12 09:00
PHST- 2005/01/12 09:00 [pubmed]
PHST- 2006/04/01 09:00 [medline]
PHST- 2005/01/12 09:00 [entrez]
AID - 1000467X20050047 [pii]
PST - ppublish
SO  - Ai Zheng. 2005 Jan;24(1):47-52.