PMID- 15642390
OWN - NLM
STAT- MEDLINE
DCOM- 20050413
LR  - 20050111
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 156
IP  - 2
DP  - 2005 Jan 15
TI  - Frequent aberrations of chromosome 8 in aggressive B-cell non-Hodgkin lymphoma.
PG  - 114-21
AB  - Translocations involving chromosome 8 are the most common aberrations in B-cell 
      non-Hodgkin lymphoma (B-NHL). The presence of the typical t(8;14)(q24;q32) or its 
      variants has been confirmed in all cases of Burkitt lymphoma (BL), in some cases 
      of Burkitt-like lymphoma (BLL), and in diffuse large B-cell lymphoma (DLBCL). The 
      alterations lead to deregulated expression of c-myc protein by a chromosomal 
      translocation joining C-MYC gene with sequences from immunoglobulin (Ig) 
      enhancers. The C-MYC gene rearrangement plays an essential role in leukemogenesis 
      of BL and probably plays a part in other aggressive NHLs. The present study was 
      undertaken to compare the cytogenetic features in cases of BL, BLL, and DLBCL. We 
      detected chromosomal aberrations by G-banding and fluorescence in situ 
      hybridization (FISH) painting in 10 cases of aggressive B-NHL and used FISH to 
      visualize the C-MYC gene rearrangement. Chromosome 8 was most frequently involved 
      in structural aberrations (8/10 cases), and 4 cases showed the typical 
      t(8;14)(q24;q32). Only two of 5 patients suspected of having BL fulfilled all the 
      criteria for this diagnosis; in the others, chromosome 8 was aberrant, but the 
      absence of C-MYC rearrangement or the results of flow cytometry excluded the 
      diagnosis of BL. All BLL cases showed C-MYC overexpression, but only one had a 
      rearrangement of the C-MYC gene; the remaining cases showed other aberrations of 
      chromosome 8. This study indicates that the mechanisms of C-MYC activation 
      involved in BLL can be different from that for the BL.
FAU - Pienkowska-Grela, Barbara
AU  - Pienkowska-Grela B
AD  - Cytogenetic Laboratory, The Memorial M. Sklodowska-Curie Cancer Centre and 
      Institute, Roentgen Str 5, 02-781 Warsaw, Poland. barpien@coi.waw.pl
FAU - Witkowska, Anna
AU  - Witkowska A
FAU - Grygalewicz, Beata
AU  - Grygalewicz B
FAU - Rymkiewicz, Grzegorz
AU  - Rymkiewicz G
FAU - Rygier, Jolanta
AU  - Rygier J
FAU - Woroniecka, Renata
AU  - Woroniecka R
FAU - Walewski, Jan
AU  - Walewski J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Chromosome Aberrations
MH  - Chromosome Banding
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 14
MH  - *Chromosomes, Human, Pair 8
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Lymphoma, B-Cell/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Translocation, Genetic
MH  - Tumor Cells, Cultured
EDAT- 2005/01/12 09:00
MHDA- 2005/04/14 09:00
CRDT- 2005/01/12 09:00
PHST- 2004/02/10 00:00 [received]
PHST- 2004/04/05 00:00 [revised]
PHST- 2004/04/15 00:00 [accepted]
PHST- 2005/01/12 09:00 [pubmed]
PHST- 2005/04/14 09:00 [medline]
PHST- 2005/01/12 09:00 [entrez]
AID - S0165-4608(04)00177-3 [pii]
AID - 10.1016/j.cancergencyto.2004.04.009 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2005 Jan 15;156(2):114-21. doi: 
      10.1016/j.cancergencyto.2004.04.009.