PMID- 15642391
OWN - NLM
STAT- MEDLINE
DCOM- 20050413
LR  - 20061115
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 156
IP  - 2
DP  - 2005 Jan 15
TI  - Recurrent genomic imbalances in B-cell splenic marginal-zone lymphoma revealed by 
      comparative genomic hybridization.
PG  - 122-8
AB  - The cytogenetics of splenic marginal zone lymphoma (SMZL) is less well 
      characterized than the cytogenetics of other non-Hodgkin B-cell lymphomas. The 
      aim of this study was to address this issue by identifying characteristic copy 
      number imbalances in SMZL, for which purpose we analyzed 20 SMZL cases by 
      comparative genomic hybridization (CGH), adding chromosome banding and 
      fluorescence in situ hybridization (FISH) in some cases. CGH identified copy 
      number imbalances in 70% of the cases. Imbalances were recurrently observed for 
      chromosomes 3 (20%), 6 (20%), 7 (25%), 12 (20%), and 14 (10%). The minimally 
      involved regions of these chromosomes were gains of 3q25 approximately qter and 
      12q13 approximately q15, and loss of 6q23, 7q31, and 14q22 approximately q24. A 
      compilation of our data with data from 3 previous SMZL CGH studies revealed a 
      significant heterogeneity between the studies. Eleven imbalances were recurrently 
      observed in the compiled data set, as opposed to only 5 in our data set. The most 
      frequently observed imbalances in the 73 SMZL cases of the compiled data set were 
      gains of 3q (27%) and 12q (15%), and loss of 7q (18%). Our data suggest that SMZL 
      constitute a genetically heterogeneous disease where gain of 3q25 and loss of 
      7q31 are the most likely imbalances to be involved in the pathogenesis of the 
      disease.
FAU - Andersen, Claus L
AU  - Andersen CL
AD  - Department of Hematology, Laboratory of Cancer Cytogenetics, Arhus Sygehus, Tage 
      Hansens Gade 2, DK-8000 Arhus C, Denmark.
FAU - Gruszka-Westwood, Alicja
AU  - Gruszka-Westwood A
FAU - Atkinson, Shayne
AU  - Atkinson S
FAU - Matutes, Estella
AU  - Matutes E
FAU - Catovsky, Daniel
AU  - Catovsky D
FAU - Pedersen, Rikke K
AU  - Pedersen RK
FAU - Pedersen, Bjarne B
AU  - Pedersen BB
FAU - Pulczynski, Stanislaw
AU  - Pulczynski S
FAU - Hokland, Peter
AU  - Hokland P
FAU - Jacobsen, Elisa
AU  - Jacobsen E
FAU - Koch, Jorn
AU  - Koch J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (DNA, Neoplasm)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosome Aberrations
MH  - Chromosome Mapping
MH  - DNA, Neoplasm/genetics/isolation & purification
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, B-Cell/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Nucleic Acid Hybridization/methods
MH  - Splenic Neoplasms/*genetics
EDAT- 2005/01/12 09:00
MHDA- 2005/04/14 09:00
CRDT- 2005/01/12 09:00
PHST- 2003/11/18 00:00 [received]
PHST- 2004/04/27 00:00 [revised]
PHST- 2004/04/28 00:00 [accepted]
PHST- 2005/01/12 09:00 [pubmed]
PHST- 2005/04/14 09:00 [medline]
PHST- 2005/01/12 09:00 [entrez]
AID - S0165-4608(04)00207-9 [pii]
AID - 10.1016/j.cancergencyto.2004.04.026 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2005 Jan 15;156(2):122-8. doi: 
      10.1016/j.cancergencyto.2004.04.026.