PMID- 15642392
OWN - NLM
STAT- MEDLINE
DCOM- 20050413
LR  - 20211203
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 156
IP  - 2
DP  - 2005 Jan 15
TI  - TEL-AML1 frequency in multi-ethnic Malaysian pediatric acute lymphoblastic 
      leukemia.
PG  - 129-33
AB  - Eighty-eight multi-ethnic Malaysian pediatric acute lymphoblastic leukemia (ALL) 
      patients were screened for the TEL-AML1 rearrangement by reverse 
      transcription-polymerase chain reaction (RT-PCR). Fluorescence in situ 
      hybridization (FISH) was used as an independent screen for 30 cases and to 
      confirm RT-PCR positive cases. Seventeen patients, or 19%, were found to be 
      t(12;21) positive. Ethnically the group comprised 12 Malays, 4 Chinese, and 1 
      Indian. All patients, including 1 with an unusual blast cell morphology who 
      suffered an early relapse and death, were characteristic TEL-AML1 cases in cell 
      count, age, ALL subset classification, and fusion transcript expressed. This 
      study shows that in Malaysia, TEL-AML1 is found in the same distinct ALL subset 
      and at a similar frequency as in other diverse childhood ALL cohorts.
FAU - Gill, Harvindar Kaur
AU  - Gill HK
AD  - Allergy & Immunology Research Centre, Institute for Medical Research, Jalan 
      Pahang, 50588 Kuala Lumpur, Malaysia. gilhk@imr.gov.my
FAU - Keoh, Ten Sew
AU  - Keoh TS
FAU - Dhaliwal, Jasbir Singh
AU  - Dhaliwal JS
FAU - Moore, Sarah
AU  - Moore S
FAU - Kim, Tan Sew
AU  - Kim TS
FAU - Hassan, Roshida
AU  - Hassan R
FAU - Karim, Faraiza Abdul
AU  - Karim FA
FAU - Zakaria, Zubaidah
AU  - Zakaria Z
FAU - Murad, Shahnaz
AU  - Murad S
FAU - Mohamed, Mahfuzah
AU  - Mohamed M
FAU - Li Ho, Caroline Mei
AU  - Li Ho CM
FAU - Ibrahim, Hishamshah
AU  - Ibrahim H
FAU - Rahman, Eni Juraida Abdul
AU  - Rahman EJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Core Binding Factor Alpha 2 Subunit)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (TEL-AML1 fusion protein)
SB  - IM
MH  - Bone Marrow/pathology
MH  - Child
MH  - Child, Preschool
MH  - China/ethnology
MH  - Core Binding Factor Alpha 2 Subunit
MH  - Ethnicity/genetics
MH  - Female
MH  - Gene Rearrangement
MH  - Humans
MH  - Immunophenotyping
MH  - India/ethnology
MH  - Malaysia
MH  - Male
MH  - Oncogene Proteins, Fusion/*genetics
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics/pathology
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2005/01/12 09:00
MHDA- 2005/04/14 09:00
CRDT- 2005/01/12 09:00
PHST- 2004/03/29 00:00 [received]
PHST- 2004/04/23 00:00 [revised]
PHST- 2004/04/28 00:00 [accepted]
PHST- 2005/01/12 09:00 [pubmed]
PHST- 2005/04/14 09:00 [medline]
PHST- 2005/01/12 09:00 [entrez]
AID - S0165-4608(04)00208-0 [pii]
AID - 10.1016/j.cancergencyto.2004.04.027 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2005 Jan 15;156(2):129-33. doi: 
      10.1016/j.cancergencyto.2004.04.027.