PMID- 15642400
OWN - NLM
STAT- MEDLINE
DCOM- 20050413
LR  - 20091119
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 156
IP  - 2
DP  - 2005 Jan 15
TI  - Clonality analysis of cell lineages in acute myeloid leukemia with inversion 16.
PG  - 175-8
AB  - Bone marrow from 5 patients with acute myeloid leukemia with inversion 16, 
      inv(16), was studied by a combination of fluorescence activated cell sorting 
      (FACS) and fluorescence in situ hybridization (FISH) to establish the extent of 
      cell-lineage involvement of inv(16). In all cases, interphase FISH demonstrated 
      the inv(16) in 80-92% of blasts, monocytes, granulocytes, and a proportion of 
      B-cells (21-41%). In contrast, inv(16) was not detectable above threshold levels 
      in mature T-cells. The current study provides a direct evidence for the clonal 
      involvement of myeloid lineage cells and B-lymphocytes and suggests that T-cells 
      are not part of the malignant clone in this disease.
FAU - Chang, Hong
AU  - Chang H
AD  - Department of Laboratory Hematology, Princess Margaret Hospital, University 
      Health Network, 610 University Avenue, 4-320 Toronto, ON, M5G 2M9, Canada. 
      hong.chang@uhn.on.ca
FAU - Nayar, Rakash
AU  - Nayar R
FAU - Li, Dan
AU  - Li D
FAU - Sutherland, D Robert
AU  - Sutherland DR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Aged
MH  - Bone Marrow Cells/pathology
MH  - Chromosome Inversion/*genetics
MH  - *Chromosomes, Human, Pair 16
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Myeloid/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - T-Lymphocytes/pathology
EDAT- 2005/01/12 09:00
MHDA- 2005/04/14 09:00
CRDT- 2005/01/12 09:00
PHST- 2004/02/17 00:00 [received]
PHST- 2004/03/22 00:00 [revised]
PHST- 2004/03/23 00:00 [accepted]
PHST- 2005/01/12 09:00 [pubmed]
PHST- 2005/04/14 09:00 [medline]
PHST- 2005/01/12 09:00 [entrez]
AID - S0165-4608(04)00164-5 [pii]
AID - 10.1016/j.cancergencyto.2004.03.017 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2005 Jan 15;156(2):175-8. doi: 
      10.1016/j.cancergencyto.2004.03.017.