PMID- 15642902
OWN - NLM
STAT- MEDLINE
DCOM- 20050927
LR  - 20111117
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 64
IP  - 1
DP  - 2005 Jan 11
TI  - HLA class II alleles are not a general susceptibility factor in Guillain-Barre 
      syndrome.
PG  - 44-9
AB  - OBJECTIVE: To assess whether human leukocyte antigen (HLA)-DRB1 and HLA-DQB1 
      alleles confer susceptibility to Guillain-Barre syndrome (GBS) or are related to 
      specific clinical or serologic subgroups of GBS. METHODS: The HLA-DRB1 and 
      HLA-DQB1 loci were genotyped by PCR amplification with sequence-specific primers 
      in 164 well-documented Dutch patients with GBS and 207 healthy Dutch control 
      subjects. Patients with GBS were divided into subgroups based on clinical 
      features, severity of disease, antecedent infection, and anti-ganglioside 
      antibodies. Data were compared with those of all case-control HLA studies in GBS 
      performed previously. RESULTS: In this case-control study, HLA-DRB1 and HLA-DQB1 
      alleles did not differ between GBS patients and control subjects. The frequency 
      of HLA-DRB1*01 was increased in patients who needed mechanical ventilation (odds 
      ratio 4.2; 95% CI 1.9 to 9.6; p(c) = 0.02). Multivariate logistic regression 
      analysis showed that this association was independent of the severity of paresis 
      and the presence of cranial nerve involvement (all p < 0.05). There was a 
      tendency toward an association between certain HLA alleles and several 
      anti-ganglioside antibodies. CONCLUSIONS: Human leukocyte antigen (HLA) class II 
      antigens are not a general susceptibility factor in Guillain-Barre syndrome 
      (GBS). However, HLA class II alleles may be a determinant in distinct subgroups 
      of GBS, indicating the need for further exploration in large-scale studies.
FAU - Geleijns, K
AU  - Geleijns K
AD  - Department of Neurology, Erasmus Medical Center, PO Box 1738, Rm. Ee 2230, 3000 
      DR Rotterdam, The Netherlands. c.geleijns@erasmusmc.nl
FAU - Schreuder, G M Th
AU  - Schreuder GM
FAU - Jacobs, B C
AU  - Jacobs BC
FAU - Sintnicolaas, K
AU  - Sintnicolaas K
FAU - van Koningsveld, R
AU  - van Koningsveld R
FAU - Meulstee, J
AU  - Meulstee J
FAU - Laman, J D
AU  - Laman JD
FAU - van Doorn, P A
AU  - van Doorn PA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*01 antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Alleles
MH  - Case-Control Studies
MH  - Child
MH  - Female
MH  - Genes, MHC Class II/*genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Guillain-Barre Syndrome/*genetics
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Netherlands
MH  - Respiration, Artificial/statistics & numerical data
MH  - Risk Factors
MH  - Severity of Illness Index
EDAT- 2005/01/12 09:00
MHDA- 2005/09/28 09:00
CRDT- 2005/01/12 09:00
PHST- 2005/01/12 09:00 [pubmed]
PHST- 2005/09/28 09:00 [medline]
PHST- 2005/01/12 09:00 [entrez]
AID - 64/1/44 [pii]
AID - 10.1212/01.WNL.0000148727.02732.01 [doi]
PST - ppublish
SO  - Neurology. 2005 Jan 11;64(1):44-9. doi: 10.1212/01.WNL.0000148727.02732.01.