PMID- 15643010
OWN - NLM
STAT- MEDLINE
DCOM- 20050616
LR  - 20181113
IS  - 1071-412X (Print)
IS  - 1098-6588 (Electronic)
IS  - 1071-412X (Linking)
VI  - 12
IP  - 1
DP  - 2005 Jan
TI  - Susceptible and protective human leukocyte antigen class II alleles and 
      haplotypes in bahraini type 2 (non-insulin-dependent) diabetes mellitus patients.
PG  - 213-7
AB  - Whereas the genetic risk for type 1 diabetes is linked to human leukocyte antigen 
      (HLA) class II genes, the HLA association in type 2 (non-insulin-dependent) 
      diabetes is less clear. The association between HLA class II genotypes and type 2 
      diabetes was examined in adult Bahrainis, an Arab population with a high 
      prevalence of type 2 diabetes. HLA-DRB1* and -DQB1* genotyping of 86 unrelated 
      type 2 diabetes patients (age, 51.6+/-8.2 years; mean duration of diabetes, 
      7.7+/-7.1 years) who had a strong family history of diabetes (52 of 72 versus 0 
      of 89 for controls, P<0.001) and 89 healthy subjects was done by 
      PCR-sequence-specific priming. DRB1*040101 (0.1221 versus 0.0562, P=0.019) and 
      DRB1*070101 (0.2151 versus 0.0843, P<0.001) were positively associated, while 
      DRB1*110101 (0.0698 versus 0.1461, P=0.014) and DRB1*160101 (0.0640 versus 
      0.1236, P=0.038) were negatively associated with type 2 diabetes. 
      DRB1*040101-DQB1*0302 (0.069 versus 0.0007; P=0.004), DRB1*070101-DQB1*0201 
      (0.178 versus 0.0761, P=0.007), DRB1*070101-DQB1*050101 (0.125 versus 0.0310, 
      P=0.002), and DRB1*150101-DQB1*060101 (0.0756 versus 0.0281, P=0.008) were more 
      prevalent among patients, while DRB1*160101-DQB1*050101 (0.0702 versus 0.0349, 
      P=0.05) was more prevalent among controls, conferring disease susceptibility or 
      protection, respectively. In Bahrainis with type 2 diabetes, there is a 
      significant association with select HLA class II genotypes, which were distinct 
      from those in type 1 diabetes.
FAU - Motala, Ayesha A
AU  - Motala AA
AD  - Nelson R. Mandela School of Medicine, University of Natal, Durban, South Africa.
FAU - Busson, Marc
AU  - Busson M
FAU - Al-Harbi, Einas M
AU  - Al-Harbi EM
FAU - Khuzam, Manal A A
AU  - Khuzam MA
FAU - Al-Omari, Emtiaz M D
AU  - Al-Omari EM
FAU - Arekat, Mona R
AU  - Arekat MR
FAU - Almawi, Wassim Y
AU  - Almawi WY
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Clin Diagn Lab Immunol
JT  - Clinical and diagnostic laboratory immunology
JID - 9421292
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*11:01:01 antigen)
SB  - IM
MH  - Bahrain
MH  - Diabetes Mellitus, Type 1/genetics
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Middle Aged
PMC - PMC540220
EDAT- 2005/01/12 09:00
MHDA- 2005/06/17 09:00
PMCR- 2005/01/01
CRDT- 2005/01/12 09:00
PHST- 2005/01/12 09:00 [pubmed]
PHST- 2005/06/17 09:00 [medline]
PHST- 2005/01/12 09:00 [entrez]
PHST- 2005/01/01 00:00 [pmc-release]
AID - 12/1/213 [pii]
AID - 0247-04 [pii]
AID - 10.1128/CDLI.12.1.213-217.2005 [doi]
PST - ppublish
SO  - Clin Diagn Lab Immunol. 2005 Jan;12(1):213-7. doi: 
      10.1128/CDLI.12.1.213-217.2005.