PMID- 15644937
OWN - NLM
STAT- MEDLINE
DCOM- 20050601
LR  - 20181201
IS  - 0008-4212 (Print)
IS  - 0008-4212 (Linking)
VI  - 82
IP  - 11
DP  - 2004 Nov
TI  - Long-term effects of the PPAR gamma activator pioglitazone on cardiac 
      inflammation in stroke-prone spontaneously hypertensive rats.
PG  - 976-85
AB  - We investigated the long-term effects of the thiazolidinedione PPARgamma 
      activator pioglitazone on cardiac inflammation in stroke-prone spontaneously 
      hypertensive rats (SHRSP), a model of malignant of hypertension. Six-week-old 
      SHRSP were treated with pioglitazone (10 mg/kg per day p.o.) for 20 weeks. The 
      rise in systolic blood pressure (SBP) in SHRSP was only transiently and slightly 
      attenuated by pioglitazone (P < 0.05). On one hand, cardiac hypertrophy was 
      little affected by the pioglitazone treatment, and there was only a reduction of 
      subepicardial interstitial fibrosis. On the other hand, left ventricular NFkappaB 
      and AP-1 binding activities, the expression of TNFalpha, and the adhesion of 
      molecule PECAM were significantly decreased by pioglitazone treatment. Expression 
      of the pro-apoptotic proteins p53 and bax was significantly increased by 
      pioglitazone. Thus, pioglitazone-attenuated cardiac inflammation in SHRSP had 
      little effect on BP or cardiac hypertrophy. PPARgamma activation may play a 
      preventive cardiovascular role by offsetting the cardiac inflammatory response as 
      demonstrated in this genetic model of malignant hypertension.
FAU - Diep, Quy N
AU  - Diep QN
AD  - CIHR Multidisciplinary Research Group on Hypertension, Clinical Research 
      Institute of Montreal, QC, Canada.
FAU - Amiri, Farhad
AU  - Amiri F
FAU - Benkirane, Karim
AU  - Benkirane K
FAU - Paradis, Pierre
AU  - Paradis P
FAU - Schiffrin, Ernesto L
AU  - Schiffrin EL
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Canada
TA  - Can J Physiol Pharmacol
JT  - Canadian journal of physiology and pharmacology
JID - 0372712
RN  - 0 (PPAR gamma)
RN  - 0 (Thiazolidinediones)
RN  - X4OV71U42S (Pioglitazone)
SB  - IM
MH  - Animals
MH  - Hypertension/*drug therapy/metabolism/pathology
MH  - Hypertrophy, Left Ventricular/drug therapy/metabolism/pathology
MH  - Male
MH  - Myocarditis/*drug therapy/metabolism/pathology
MH  - PPAR gamma/agonists/*metabolism
MH  - Pioglitazone
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Stroke/*drug therapy/metabolism/pathology
MH  - Thiazolidinediones/pharmacology/*therapeutic use
MH  - Time Factors
EDAT- 2005/01/13 09:00
MHDA- 2005/06/02 09:00
CRDT- 2005/01/13 09:00
PHST- 2005/01/13 09:00 [pubmed]
PHST- 2005/06/02 09:00 [medline]
PHST- 2005/01/13 09:00 [entrez]
AID - y04-094 [pii]
AID - 10.1139/y04-094 [doi]
PST - ppublish
SO  - Can J Physiol Pharmacol. 2004 Nov;82(11):976-85. doi: 10.1139/y04-094.