PMID- 15646665
OWN - NLM
STAT- MEDLINE
DCOM- 20050404
LR  - 20200423
IS  - 1050-0545 (Print)
IS  - 1050-0545 (Linking)
VI  - 15
IP  - 10
DP  - 2004 Nov-Dec
TI  - Interactions among variables in the P300 response to a continuous performance 
      task in normal and ADHD adults.
PG  - 666-77
AB  - This study investigated the effect of variable interstimulus intervals (ISIs) in 
      a group of normal and ADHD (attention deficit hyperactivity disorder) adults on 
      behavioral reaction time and the auditory P300 event-related potential. This 
      study involved 20 adult subjects with no history of ADHD and 11 adult subjects 
      diagnosed with ADHD. The subjects were instructed to respond to the common 
      stimuli and ignore the rare stimulus. Significant differences in the latency of 
      the P300a, P300b, the amplitude of the P300b, and in the number of false alarms 
      and correct rejections between ISIs were observed in the normal group. The group 
      with ADHD failed to show any significant differences between ISIs. Psychophysical 
      measures of hits showed significant differences for the number of hits for ISI 2 
      (2 sec) between the two groups. False alarms and correct rejections for all ISIs 
      showed significant differences between groups. Significant group differences were 
      seen for latency of the P300a and P300b at each of the three ISIs, for amplitude 
      of the P300a and P300b for ISI 1 and ISI 3, and for the amplitude of the P300b 
      for ISI 2. There was a greater separation in the group with ADHD between the 
      P300a and P300b suggesting a processing lag in that group.
FAU - McPherson, David L
AU  - McPherson DL
AD  - Brigham Young University, Provo, Utah, USA. david_mcpherson@byu.edu
FAU - Salamat, Mimi T
AU  - Salamat MT
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Am Acad Audiol
JT  - Journal of the American Academy of Audiology
JID - 9114646
SB  - IM
MH  - Acoustic Stimulation
MH  - Adolescent
MH  - Adult
MH  - Analysis of Variance
MH  - Arousal/physiology
MH  - Attention Deficit Disorder with Hyperactivity/*physiopathology
MH  - Audiometry, Evoked Response/methods
MH  - Case-Control Studies
MH  - Cognition/physiology
MH  - Event-Related Potentials, P300/*physiology
MH  - Evoked Potentials, Auditory/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Reaction Time/physiology
MH  - Regression Analysis
EDAT- 2005/01/14 09:00
MHDA- 2005/04/05 09:00
CRDT- 2005/01/14 09:00
PHST- 2005/01/14 09:00 [pubmed]
PHST- 2005/04/05 09:00 [medline]
PHST- 2005/01/14 09:00 [entrez]
AID - 10.3766/jaaa.15.10.2 [doi]
PST - ppublish
SO  - J Am Acad Audiol. 2004 Nov-Dec;15(10):666-77. doi: 10.3766/jaaa.15.10.2.