PMID- 15650879
OWN - NLM
STAT- MEDLINE
DCOM- 20050421
LR  - 20220227
IS  - 0093-7711 (Print)
IS  - 0093-7711 (Linking)
VI  - 56
IP  - 11
DP  - 2005 Feb
TI  - HLA polymorphisms are associated with Helicobacter pylori infected gastric cancer 
      in a high risk population, China.
PG  - 781-7
AB  - Helicobacter pylori is one of the most common bacterial infections associated 
      with an increased risk of gastric cancer, but its association with host factors, 
      particularly polymorphisms of the immune response genes, such as human leukocyte 
      antigen (HLA) genes, is still unclear. To investigate the role of HLA 
      polymorphisms in the risk of gastric cancer among subjects with H. pylori 
      infection, a case-control study involving 52 gastric cancer patients and 139 
      non-cancer controls was conducted in Linqu County, China, an area with a high 
      incidence of gastric cancer. Polymorphisms of HLA class I and class II alleles 
      were determined by PCR with sequence-specific primers (PCR-SSP). The information 
      about H. pylori infection was obtained from previous records. Among 48 class I 
      and 19 class II HLA alleles detected in this study, two alleles, CW*03 and 
      DRB1*01, were found to be distributed significantly differently between patients 
      and controls [odds ratio(OR)=1.95, 95% confidence interval (CI)=1.13-3.35, 
      P=0.017 and OR=4.39, 95% CI=1.39-13.84, P=0.012, respectively). The OR of gastric 
      cancer risk in individuals carrying CW*03/CW*03 or CW*03/CW*N was 2.06, 95% 
      CI=1.05-4.02, P=0.035, while the OR was 3.49, 95% CI=1.0-12.4, P=0.04 for 
      DRB1*01/DRB1*01 or DRB1*01/DRB1*N carriers. The analysis of the interaction 
      between H. pylori infection and HLA risk genotypes of CW*03 or DRB1*01 revealed 
      that the effect of CW*03 and DRB1*01 genotypes on gastric cancer risk was 
      manifested stronger in H. pylori-positive individuals (OR=5.30, 95% 
      CI=1.73-16.29, P=0.004 and OR=13.38, 95% CI=2.52-70.98, P=0.002, respectively) 
      than in H. pylori-negative ones (OR=1.25, 95% CI=0.25-6.12, P=0.785 and OR=2.26, 
      95% CI=0.18-28.88, P=0.531, respectively). The combined effect of the two risk 
      HLA genotypes on gastric cancer risk was also analysed. The result showed that 
      the individuals carrying both the CW*03 and DRB1*01 alleles could only be found 
      in cancer patients (5/52), and not in controls (0/139), further suggesting that 
      CW*03 and DRB1*01 are risk alleles advancing the progression of tumorigenesis. 
      These observations demonstrate that host HLA genotypes may play an important role 
      in the risk of gastric cancer, especially among persons with H. pylori infection.
FAU - Li, Zhaohui
AU  - Li Z
AD  - Department of General Surgery, Qilu Hospital of Shandong University, Jinan, 
      People's Republic of China.
FAU - Chen, Dafang
AU  - Chen D
FAU - Zhang, Chunfeng
AU  - Zhang C
FAU - Li, Yong
AU  - Li Y
FAU - Cao, Bangwei
AU  - Cao B
FAU - Ning, Tao
AU  - Ning T
FAU - Zhao, Yiming
AU  - Zhao Y
FAU - You, Weicheng
AU  - You W
FAU - Ke, Yang
AU  - Ke Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050114
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 0 (HLA Antigens)
SB  - IM
MH  - China
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA Antigens/*genetics/immunology
MH  - Helicobacter Infections/genetics/*immunology
MH  - Helicobacter pylori
MH  - Humans
MH  - Male
MH  - Polymorphism, Genetic
MH  - Stomach Neoplasms/genetics/*immunology
EDAT- 2005/01/15 09:00
MHDA- 2005/04/22 09:00
CRDT- 2005/01/15 09:00
PHST- 2004/05/20 00:00 [received]
PHST- 2004/08/31 00:00 [revised]
PHST- 2005/01/15 09:00 [pubmed]
PHST- 2005/04/22 09:00 [medline]
PHST- 2005/01/15 09:00 [entrez]
AID - 10.1007/s00251-004-0723-9 [doi]
PST - ppublish
SO  - Immunogenetics. 2005 Feb;56(11):781-7. doi: 10.1007/s00251-004-0723-9. Epub 2005 
      Jan 14.